The Citric Acid Cycle Flashcards

1
Q

What is necessary in the cell for the citric acid cycle to occur?

A

Mitochondria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the function of coenzyme A?

A

Coenzyme A (A for acetylation) was found as a cofactor for the acetylation reactions and is needed for pyruvate oxidation and to participate in citric acid synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does the oxidation of AcCoA produce?

A

3 NADH
1 FADH2
1 GTP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Where are the TCA cycle enzymes found?

A

Mitochondrial Matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Where does the ATP in the TCA cycle come from?

A

The transfer of electrons from substrates to molecular oxygen provides the energy to synthesize ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What TCA enzymes are controlled by allosteric regulation?

A

Isocitrate Dehydrogenase

α-ketoglutarate Dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What will increased ADP do to the TCA cycle?

A

The CAC (citric acid cycle) activity will be increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What happens with a decreased supply of acetyl-CoA?

A

Pyruvate dehydrogenase activity will increase to convert glucose to AcCoA.

Fatty acid oxidation into AcCoA will increase.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the most common cause of pyruvate dehydrogenase deficiency?

A

The most common form of pyruvate dehydrogenase deficiency is caused by mutations in the E1 alpha gene, and is inherited in an X-linked dominant manner.

All other forms are caused by various genes and are inherited in an autlosomal recessive manner.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the symptoms of pyruvate dehydrogenase deficiency?

A

Children with pyruvate dehydrogenase deficiency exhibit elevated serum levels of lactate, pyruvate and alanine, which produce a chronic lactic acidosis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the symptoms of fumarase deficiency?

A
  • Severe neurological impairment

- Increased urinary excretion of fumarate, succinate, alpha keto-glutarate and citrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly