The Normal Cell(Ultrastructure) Flashcards
(20 cards)
Who was the first to identify a cell and when
Robert Hooke
1665
Cell theory was proposed in
1885
Broad division of cell
Prokaryotes - Bacteria, Blue green algae
Eukaryotes - Animals, Plants, other organisms
Peptidoglycan is present in the cell wall of
Prokaryotes
Prokaryotes undergo mitosis T/F
F. Eukaryotes do
Sterols are present in the cell membrane of
Eukaryotes
The phospholipid bilayer is Ampiphatic. It has
Hydrophilic heads
Hydrophobic tails
The PM contains 3 types of proteins
Intrinsic/Integral
Extrinsic/Peripheral
Transmembrane
Functions of Proteins in PM
Cell to cell recognition
Anchorage
Transport
Enzymatic activity
Intercellular joining
Signal Transduction
PM is destroyed in Necrosis/Apoptosis
Necrosis
Pathology correlates of membrane proteins
Hereditary stomatocytosis in RBCs
Cystic Fibrosis
Wilson’s disease
In Hereditary Stomatocytosis in RBCs,
Marked increase of intracellular Na because the cell is unable to regulate cation homeostasis
In Cystic Fibrosis,
Mutation in CFTR gene leading to production of abnormally folded membrane protein which is degraded by the cell
In Wilson’s disease,
Mutation in Wilson disease protein (ATP7B) leading to Cu accumulation
The most obvious feature of the cell seen under the light microscope
Nucleus
Ribosomopathies
- Diamond Blackfan anemia-Defects in RPS 19,24
- 5q syndrome-Defects in RPS 14. May progress to AML
Pathology correlates of mitochondria
Leigh syndrome-Regression in motor skills
Pathological correlates of golgi apparatus
Alzheimer’s
Parkinson’s
Lysosomal storage diseases
Gaucher’s
Niemann Pick disease
Peroxisomes contain
Oxidases
Catalases
