Therapeutic Antibodies

Question 1

Alemtuzumab

Answer 1

CD 52 for CLL and MS

Question 2

Bevacizumab

Answer 2

VEGF for Colorectal cancer, renal cell carcinoma. Macular degeneration

Question 3

Cetuximab

Answer 3

EGFR for Stage IV colorectal cancer, head and neck cancer

Question 4

Rituximab

Answer 4

CD 20 for Bcell non Hodgkin lymphoma, CLL, RA, ITP

Question 5

Trastuzumab

Answer 5

Her2/neu for Breast Ca.

Question 6

Adalimumab

Answer 6

Soluble TNF-a for IBD, RA, ankylosing spondylitis, psoriasis

Question 7

Certolizumab

Answer 7

Soluble TNF-a for IBD, RA, ankylosing spondylitis, psoriasis

Question 8

Etanercept

Answer 8

Decoy TNF a R and not a monoclonal ab

Question 9

Infliximab

Answer 9

Soluble TNF-a for IBD, RA, ankylosing spondylitis, psoriasis

Question 10

Natalizumab

Answer 10

alpha4 integrin for MS, and Crohn. Risk of PML in patients with JC virus

Question 11

Abciximab

Answer 11

Platelet glycoproteins IIb/IIIa, Antiplatelet for PCI

Question 12

Denosumab

Answer 12

RANKL for osteoporosis

Question 13

Digoxin immune Fab

Answer 13

Digoxin

Question 14

Omalizumab

Answer 14

IgE for allergic asthma, prevents IgE binding to FceRI

Question 15

Palivizumab

Answer 15

RSV F protein, prophylaxis for high risk infants

Question 16

Ranibizumab, bevacizumab

Answer 16

VEGF, neovascular age-related macular deneration

Question 17

SE of glucocorticoids

Answer 17

Hyperglycemia, osteoporosis, central obesity, muscle breakdown, psychosis, acne, hypertension, cataracts, avascular necrosis

Question 18

Aldesleukin

Answer 18

IL2.

RCC, metastatic melanoma

Question 19

Filgrastim and Sargramostim

Answer 19

G and GM-CSF for recovery of bone marrow.

Question 20

IFN a uses

Answer 20

Chronic hep B and C, Kaposi’s Sarcoma, Malignant Melanoma

Question 21

IFN b uses

Answer 21

Multiple sclerosis

Question 22

IFN gamma uses

Answer 22

Chronic granulomatous Disease