Therapeutic mAbs and cytokines Flashcards Preview

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Flashcards in Therapeutic mAbs and cytokines Deck (20)
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1

Basiliximab / Dacluzimab

Target: IL-2 receptor on T cells

Used in kidney transplant rejection prophylaxis

Side effects: Edema, hypertension, tremor

2

Bevacizumab

Target: VEGF

Used in colorectal cancer and renal cell carcinoma

3

Cetuximab

Target: EGFR

Used in stage IV colorectal cancer

4

Rituximab

Target: CD20 on B cells

Used in B-cell non-Hodgkin lymphomas, rheumatoid arthritis (along with MTX) and immune thrombocytopenia

5

Trastuzumab

Target: HER2/neu receptor

Used in HER2+ breast cancer

6

Infliximab / Adalimumab

Target: TNF-alpha

Used in inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, and psoriasis

*Always do PPD test first; anti-TNF activity can re-activate latent TB

7

Abciximab

Target: Glycoprotein IIb/IIIa on platelets

Used as anti-platelet therapy for patients undergoing percutaneous coronary intervention

8

Denosumab

Target: RANKL

Used in osteoporosis; inhibits osteoclast maturation

9

Omalizumab

Target: IgE

Used in allergic asthma

10

Palivizumab

Target: RSV F protein

Used as RSV prophylaxis in high-risk infants

11

Natalizumab

Target: alpha4-integrin (involved in leukocyte adhesion)

Used in Multiple Sclerosis and Crohn's Disease

*Risk of PML in patients with JC virus

12

Epoetin alfa (erythropoietin)

Used to treat anemias, especially in renal failure

13

Thrombopoietin

Used to treat thrombocytopenia

14

Oprelvekin (interleukin-11)

Used to treat thrombocytopenia

15

Filgrastim

AKA granulocyte colony-stimulating factor (G-CSF)

Recovery of bone marrow

16

Sargramostim

AKA granulocyte/macrophage colony-stimulating factor

Recovery of bone marrow

17

Aldesleukin (IL-2)

Renal cell carcinoma, metastatic melanoma

18

IFN-alpha

Chronic hepatitis B and C
Kaposi sarcoma
Hairy cell leukemia
Condyloma acuminatum
Renal cell carcinoma
Malignant melanoma

19

IFN-beta

Multiple Sclerosis

20

IFN-y

Chronic granulomatous disease