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Flashcards in Cancer Drugs Deck (9)
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1

Vinblastine: MOA, SE

MOA:
* inhibits MT formation of mitotic spindle SE:
* alopecia
* constipation
* myelosuppression
* neurotoxicity (rare)

2

Cancer drugs that act in the M phase of the cell cycle

vinca alkaloids=inhibit MT fxn/spindle formation
* vincristine
* vinblastine paclitaxel 
* binds to tubulin and hyperstabilizes MTs that have already polymerized ==> prevents spindle breakdown

3

5-fluorouracil: MOA, use


* anti-metabolite
* prevents formation of thymidine vua inhibition of thymidylate synthase uses
* slow-growing solid tumors:
* breast
* ovarian
* pancreatic
* colorectal
* gastric carcinomas

4

6-mercaptopurine: MOA, use


* anti-metabolite
* inhibits formation of purines
* use = cancer drug

5

Methotrexate: MOA, use


* anti-metabolite
* inhibts dihydrofolate reductase ==> inhibition of DNA synthesis (via same pathway as 5-fluorouracil)
* use = cancer drug

6

Busulfan: MOA, use


* DNA alkylating agent (cell cyle nonspecific)
* use = CML

7

Bleomycin: MOA, use, SE


* inhibit replication by inducing DNA strand breaks via free radical formation
* strand breakage interrupts G2 phase of cell cycle (after DNA synthesis)
* uses: testicular tumors, lymphomas, squamous cell carcinoma SE
* rales, cough
* infiltration ==> fibrosis

8

Cyclophosphamide: MOA, uses, SE

DNA alkylating agent (cell cycle nonspecific)
* activated by CYP450
* ==> apoptosis via DNA crosslinking uses
* leukemias, lymphomas
* testicular and gyn cancers SE
* hemorrhagic cystitis

9

How to prevent major side effect of cycloposphamide

prevent hemorrhagic cystitis via:
* adequate hdration
* IV injection of mesna