Thermoregulation and pyrexia L8 Flashcards

(57 cards)

1
Q

at what temp does denaturing occur

A

above 45 degrees

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2
Q

range of temps where there is conscious intelligence

A

35-40 degrees

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3
Q

when in the day are you coolest

A

just before you wake up

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4
Q

when in the day are you hottest

A

mid afternoon

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5
Q

rise in temperature in the menstrual cycle

A

0.5 degrees at ovulation

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6
Q

what fibres transmit temperature

A

A delta and C fibres (same as pain)

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7
Q

coordinator of thermoregulation

A

anterior hypothalamus

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8
Q

do we have more hot or cold receptors

A

more cold receptors (we are a cold species)

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9
Q

normal body temp=

A

37.5 degrees

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10
Q

heat production=

A

metabolism

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11
Q

what type of response is most important to maintain temperature

A

voluntary actions

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12
Q

e.g of voluntary actions

A

wearing a coat

wearing less clothing in the sun

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13
Q

what disadvantage do the very old and very young have

A

often can’t put clothing on themselves

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14
Q

5 changes when too cold

A
shivering 
brown fat 
skin blood flow
piloerection 
neuroendocrine
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15
Q

how much can shivering increase heat production

A

5%

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16
Q

what body movement is shivering predominately

A

truncal

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17
Q

disadvantage of shivering

A

metabolically expensive

can lose vital energy

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18
Q

who has brown fat

A

neonates and animals

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19
Q

what is brown fat (3)

A
  • adipose tissue with lots of mitochondria
  • higher blood supply than normal fat
  • Beta 3 receptors
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20
Q

what does brown fat do

A

burns fat into energy

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21
Q

2 changes in skin blood flow

A

vasodilation

vasoconstriction

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22
Q

how much can skin blood flow alter heat loss

A

8%

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23
Q

what happens to skin blood flow in prolonged cold exposure

A

paradoxical increased flow

24
Q

what Nervous system mediates skin blood flow

25
piloerection=
hairs stand on end
26
erector pili under what control
sympathetic
27
effect of erector pili
minimal effect in humans
28
what neuroendocrine effect happens when you're cold
increased catecholamines (adrenaline/ noradrenaline)
29
heat loss by conduction/convection=
60%
30
heat loss by radiation=
25%
31
heat loss by evaporation
15%
32
what system controls sweat glands
sympathetic
33
most neurotransmitters of sympathetic=
noradrenaline
34
whats different about the neurotransmitters in sweat glands
cholinergic (muscarinic)
35
3 substances filtered across in sweat
sodium chloride urea
36
what is sweat like in people who have acclimatised to heat
sweat more but more concentrated so lose less sodium
37
how much does heat loss increase by sweat
10x
38
2 abnormalities in thermoregulation
hypothermia | hyperthermia
39
hypothermia=
core temp <35 degrees
40
severe hypothermia=
<28 degrees
41
3 causes of hypothermia
behavioural hypothyroidism dermatological
42
3 clinical features of hypothermia
confusion coma cardiovascular
43
common cardio complication of hypothermia
atrial fibrillation
44
what is not advised when someone is hypothermic
defibrillation
45
management of hypothermia
ABC; airways, breathing , circulation | -controlled warming (via warming blankets
46
what can be used for extreme hypothermia in big hospitals
bypass
47
hyperthermia=
>38 degrees
48
life threatening hyperthermia=
>40 degrees
49
4 causes of hyperthermia
exertion (exercise) situational (heat stroke) Drugs pyrexia
50
4 clinical signs of hyperthermia
confusion seizures coma cardiovascular
51
what is pyrexia usually due to
altered set point
52
causes of pyrexia (5)
- infection - blood transfusion - inflammation - malignancy - hypothalamic insult
53
what in the body is a major contributor to pyrexia (drug target)
prostaglandins
54
drugs that treat pyrexia
NSAID Aspirin paracetamol
55
why do we get a fever
to get rid of pathogens
56
when is a fever bad
head injury | post cardiac arrest
57
why do we treat fever
to make people feel better