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Flashcards in Thiazide Diuretics Deck (10)
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1

What is the thiazide diuretic used in treatment?

- Bendroflumethiazide

2

What are the indications of bendroflumethiazide?

- Hypertension
- Diabetes insipidus

3

What are the containdications of bendroflumethiazide?

- Severe electrolyte disturbance
- Acute gout
- Addisons disease

4

What are examples of the electrolyte disturbances caused by bendroflumethiazide?

- Hyponatraemia
- Hypokalaemia
- Hypercalcaemia

5

Cautions of bendroflumethiazide?

- Gout
- Diabetes mellitus
- Renal impairment
- Hepatic impairment
- Pregnancy and breast feeding

6

What process do thiazide diuretics increase loss of fluid?

- Normally the Na/KATPase pump at the distal tubule in the kidney maintains a high Na conc and allows water to return
- Thiazides block the transporter and diuresis occurs

7

How should bendroflumethiazide be administered?

- Orally
- Low dose

8

What are the adverse reactions of bendroflumethiazide?

- Hypokalaemia
- Hyponatraemia
- Hypomagneaemia
- Hypercalcaemia
- Hyperuricacidaemia
- Hyperlipidaemia
- Impotence
- Blood disorders (thrombocytopenia)

9

What drug interactions are there for bendroflumethiazide?

- NSAIDs reduce their effects
- Lithium excretion reduced that can lead to toxicity

10

What can hypokalaemia from bendroflumethiazide cause?

- Digoxin toxicity if being used with
- Anti-arrhythmic toxicity