Potassium Sparing Diuretics Flashcards Preview

Cardiovascular Drugs > Potassium Sparing Diuretics > Flashcards

Flashcards in Potassium Sparing Diuretics Deck (9)
Loading flashcards...
1

Example

Amiloride

2

Indications

Adjunct to diuretic use in hypertension or heart failure (SPECIALIST USE)

3

What are the contraindications of PSDs?

- Hyperkalaemia
- Anuria
- Addisons

4

Cautions

- Diabetes mellitus
- Renal impairment
- Pregnancy and breast feeding

5

What channels does amiloride block and where are they found?

- Sodium channels
- Distal tubule
- Reduction is sodium reabsorption leads to reduction in water reabsorption

6

How is pH maintained when using amiloride?

- Potassium also lost

7

How is amiloride administered?

- Oral

8

Adverse reactions to amiloride?

- Hyperkalaemia
- Hyponatraemia
- GI upset

9

What drugs does amiloride interact with?

Drugs that increase potassium levels

- ACE-I
- Angiotensin II antagonists
- Aldosterone antagonists

These will increase the hyperkalaemia (may also occur with NSAIDs)