Thoracic

Question 1

indications for lung cancer screening (3)

Answer 1

1) 55-77
2) current or former smoker within last 15 year
3) 30 pack year history

Question 2

IHC marker for lung cancer (2)

Answer 2

CK7+, CD20-

Question 3

IHC marker for adenocarcinoma (2)

Answer 3

TTF-1, Hapsin A

Question 4

IHC marker for squamous cell (2)

Answer 4

p63+, p40+

Question 5

Prognosis of KRAS mutation (2)

Answer 5

Poor OS, does not respond to EGFR-TKIs

Question 6

What to do if resection is positive

Answer 6

R1 (microscopic) - resect or RT

R2 (macroscopic) - concurrent chemoRT

Question 7

Indication for adjuvant therapy in lung cancer

Answer 7

Stage2A+ after complete resection, often with cisplatin or carboplatin

Question 8

Treatment of Stage 3A (N2+)

Answer 8

Concurrent chemoRT

Question 9

Treatment of Stage 3A (N1)

Answer 9

Surgery + adjuvant chemotherapy

Question 10

Treatment of ROS1 mutated metastatic NSCLC

Answer 10

ALK inhibitor (crizotinib)

Question 11

Analysis method for ALK

Answer 11

FISH for rearrangements

Question 12

Evaluation of mediastinal lymph nodes

Answer 12

EBUS

Question 13

Pemetrexed contraindication

Answer 13

Squamous

Question 14

IOs approved for second line regardless of PDL1 expression

Answer 14

Nivolumab and atezolizumab

Question 15

SCLC limited vs extensive stage

Answer 15

Ipsilateral hemithroax or not

Question 16

Treatment of SCLC

Answer 16

Cis/carbo + Etop + radiation if limited stage

Question 17

When to offer PCI in extensive stage SCLC

Answer 17

After complete response

Question 18

Staging in SCLC

Answer 18

MRI brain with CT C/A/P

Question 19

Most common cytogenetics in SCLC

Answer 19

3p deletion

Question 20

Treatment of SCLC after relapse

Answer 20

If >90 days with response, reinitiation chemotherapy

If <90 days, other chemo or clinical trial

Question 21

SCLC Encephalomyelitis Ab

Answer 21

Anti-Hu

Question 22

Good prognosis mesothelioma

Answer 22

Epitheloid

Question 23

First line treatment for mesothelioma

Answer 23

Carbo/Cis plus pemetrexed

Question 24

Relationship between tobacco smoke and mesothiloma

Answer 24

No relationship

Question 25

Treatment of sarcomatoid mesothelioma

Answer 25

chemo or radiation, no surgery

Question 26

Supplementation with pemetrexes

Answer 26

VitB12 and folate

Question 27

Treatment of stage I-II operable mesothelioma

Answer 27

induction chemotherapy

Question 28

Prognostic impact of MG in thymoma presentation

Answer 28

Good prognosis (presents earlier)

Question 29

Test before thymoma resection

Answer 29

Anti-AcH receptor antibody levels

Question 30

Post operative treatment of thymoma or thymic carcinoma

Answer 30

R1: radiation R2: chemoradiation (thymic carcinoma only)

Question 31

Chemotherapy for thymoma

Answer 31

Platinum based (e.g. cyclophosphamide, doxorubicin, cisplatin)

Question 32

Management of suspected resectable thymoma

Answer 32

Resect - don't biopsy

Question 33

Management of MG in thymoma

Answer 33

Control MG first, then resect

Question 34

Management of oligometastatic thymoma

Answer 34

Chemotherapy with surgical re-evaluation

Question 35

Indications for cranial radiation in SCLC

Answer 35

limited stage after CR

Question 36

First line treatment for ALK mutated lung cancer

Answer 36

Alectinib or brigatinib