Thyroid Drugs Flashcards Preview

Endo/Repro > Thyroid Drugs > Flashcards

Flashcards in Thyroid Drugs Deck (7)
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1

TH Replacement Therapy (contraindications)

Obesity, vaginal bleeding, depression

2

Synthetic T4 (4)

Levothroid, Levoxyl, Synthroid, Unithroid

3

Synthetic T3 (2)

Cytomegalovirus, Triostat

4

K-I (potassium iodide, SSKI) (uses)

Use: achieve Wolff-Chaikoff effect in hyperthyroidism (I increase temporarily inhibits T3/4 synthesis)

5

Radioactive Iodide (uses)

Uses: Graves' disease, toxic nodules, thyroid cancer

6

Propylthiouracil (PTU)

Mechanism: inhibits thyroid peroxidase and iodine organification (thus TH synthesis), and inhibits peripheral T3/T4deiodination
Use: hyperthyroid
Side effects: macupapular pruritic rash, fatal hepatitis, elevated liver enzymes, agranulocytosis.
-Safer than methimazole for pregnancy (doesnt cross placenta)

7

Methimazole

Mechanism: inhibits thyroid peroxidase and iodine organification (thus TH synthesis)
Use: hyperthyroid
Side effects: macupapular pruritic rash, fatal hepatitis, elevated liver enzymes, agranulocytosis. Also can cause aplasia cutis (lack of skin on head)
-Safer than PTU except for pregnancy (crosses placenta)