Hypothalamic/Pituitary Drugs Flashcards Preview

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Flashcards in Hypothalamic/Pituitary Drugs Deck (11)
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1

Somatropin/Somatotropin

Class: GH Analog
Mechanism: acts as agonist at GH receptors
Use: GH Deficiency, familial short stature
SE:
-kids: pseudotumor cerebri, scoliosis, edema, hyperglycemia (from insulin resistance)
-adults: edema, myalgias, arthralgias, carpal tunnel syndrome

2

Mecasermin

Class: IGF-1 analog
Mechanism: stimulates IGF-1 receptors
Use: IGF-1 deficiency due to GH resistance
SE: Hypoglycemia

3

Octreotide/Lantreotide

Class: Somatostatin agonists
Mechanism: inhibit GH
Use: acromegaly (GH-secreting tumor)
SE:
-nausea/vomiting
-cramps/gas
-gallstones
-bradycardia
-conduction disturbances

4

Pegvisomant

Class: GH antagonist
Mechanism: GH antagonist at receptor
Use: Acromegaly
SE: none

5

Urofollitropin, Follitropin å and ß

Class: FSH agonists
Mechanism: act like FSH
Use:
-Women: IVF, second line to clomiphene
-Men: kallman syndrome (infertility due to hypogonadotropic hypogonadism)
SE: ovarian hyperstimulation syndrome, multiple pregnancy

6

Lutropin å

Class: LH receptor agonist
MEchanism: acts like LH
Use: Used in IVF for LH deficient women
SE: OHSS, multiple pregnancy

7

Choriogonadotropin å

Class: LH receptor agonist
Mechanism: acts like LH
Use:
-women: IVF, secondary to clomiphene
-men: infertility from kallman syndrome
SE: OHSS, multiple pregnancy

8

Leuprolide, Goserelin, Histrelin, Nafarelin, Triptorelin

Class: GnRH agonists
Mechanism: GnRH agonists increase LH/FSH with intermittent administration, reduce with continuous administration
Use: IVF, endometriosis, uterine fibroids, prostate cancer, central precocious puberty
SE:
-Women: effects of decreased FSH/LH- menopause, depression, decreased libido, pain, vaginal dryness, breast atrophy, reduced bone density
-Men: effects of reduced testosterone- hot flashes, edema, gynecomastia, decreased libido, decreased hematocrit, reduced bone density, asthenia

9

Ganirelix, Cetrorelix, Degarelix

GnRH antagonists
Mechanism: reduce endogenous LH/FSH production
Use: IVF, advanced prostate cancer
SE: androgen deprivation (hot flashes, edema)

10

Bromocriptin/cabergoline

Dopamine agonists
Mechanism: suppress prolactin secretion
Use: hyperprolactinemia
SE: nausea, headache, lightheadedness, orthostatic hypotension, fatigue, psych, valvulopathy

11

Oxytocin

Mechanism: oxytocin receptor agonist
Use: induction of labor, control uterine hemmorhage post-delivery
SE:
-fetal distress/placental abruption/uterine rupture
-accidental ADH-like effects- fluid retention, hyponatremia, CHF, seizures