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Flashcards in Breast Cancer Drugs Deck (2)
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1

Tamoxifen, Reloxifene

Class: SERMS
Mechanism: competitive estrogen receptor antagonist
Use: ER+ breast cancers
SE: hot flushes, nausea/vomiting. INCREASED RISK ENDOMETRIAL CANCER

2

Anastrozole

Class: Aromatase inhibitor
MEchanism: prevents estrogen synthesis from androgens (androstenedione/testosterone)
SE: Hot flashes, nausea/vomiting, fracture risk