Tissue Repair, Healing and Fibrosis Flashcards Preview

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Flashcards in Tissue Repair, Healing and Fibrosis Deck (42)
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31

In the cell cycle, this is also called the premitotic growth phase.

G2(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

32

These steps in the cell cycle prevents DNA replication or mitosis of damaged cells and either transiently stop the cell cycle to allow repair, or eliminate irreversibly damaged cells by apoptosis.

Checkpoint control(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

33

These enzymes promote DNA replication and various aspects of mitosis. They are required for cell cycle progression. Forms complexes with cyclin.

Cyclin-deoendent kinases (CDK)(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.61

34

This cytokine is released from activated macrophages, and is mitogenic for keratinocytes and fibroblasts. It also stimulates keratinocyte migration and granulation tissue formation.

Epidermal Growth Factor (EGF)(TOPNOTCH)

35

This cytokine increases vascular permeability and is mitogenic for endothelial cells.

Vascular Endothelial Growth Factor (VEGF)(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.71

36

Pattern of extracellular signaling wherein the target cell is itself.

Autocrine(TOPNOTCH)

37

Pattern of extracellular signaling wherein the target cell is adjacent to the secretory cell.

Paracrine(TOPNOTCH)

38

Pattern of extracellular signaling wherein the target cell is distant to the secretory cell.

Endocrine(TOPNOTCH)

39

Synthesized by mesenchymal cells, present in the spaces between cells in connective tissue, between epithelium and supportive vascular and smooth muscle structures.

Interstitial Matrix(TOPNOTCH)

40

Component of ECM which confers tensile strength and recoil.

Fibrous proteins s.a. Collagen and elastin(TOPNOTCH)

41

Component of ECM that permits resilience and lubrication.

Proteoglycans, hyaluronan(TOPNOTCH)

42

Component of ECM that connect the elements to one another and to the cells.

Adhesive glycoproteins(TOPNOTCH)