Toxin mediated CNS infections

Question 1

Infective organism in tetanus

Answer 1

Clostridium tetani

Question 2

Affect of A-B toxin in tetanus

Answer 2

Blocks release of inhibitory neurotransmitters

Question 3

Post-exposure prophylaxis for tetanus

Answer 3

Simultaneous passive (HTIG) and active immunization
Penicillin or metronidazole
Supportive care

Question 4

Tetanus vaccine schedule for children

Answer 4

At 2, 4, 6, and 18 mos, and at 5 yrs

Question 5

Strict anaerobe with gram positive rods with prominent terminal spores

Answer 5

Clostridium tetani

Question 6

Affect of A-B toxin in botulism

Answer 6

Blocks release of Ach at cholinergic synapses

Question 7

Bilateral descending weakness of peripheral muscles and flaccid paralysis with clear sensorium after eating at a picnic

Answer 7

Botulism

Question 8

Anaerobic gram positive rod that produces spores and heat labile neurotoxin

Answer 8

Clostridium botulinum

Question 9

Habits that predispose one to skin wound botulism

Answer 9

Skin popping
Parenteral or intranasal cocaine use

Question 10

Treatment for botulism

Answer 10

Antitoxin and supportive care