Trace elements Flashcards
(53 cards)
chronic iron intoxication is called
hemochromatosis
iron is absorbed mainly in the
small intestine
the amount of light absorbed is proportional to the concentration of absorbing atoms in
Atomic absorption spectroscopy (AAS)
What does a flame atomizer do?
Aspirate a liquid sample from elements into atoms
Disadvantages to AAS
one element at a time
not suitable for all elements
sensitivity limitation
ICP-MS separates ions based on
mass-to-charge ratio
most commonly used ICP-MS
the quadrupole ICP-MS
the better ICP-MS
Magnetic sector ICP-MS
total iron content of the adult body
4g
acquired hemochromatosis can occur as a result of
multiple blood transfusions
hereditary hemochromatosis can occur as a result of
gene mutation in HFE causing increased intestinal iron absorption
Lab testing for iron deficiency
CBC
Serum ferritin
Zinc protoporphyrin (ZPP)
Lab testing for iron overload
Acute poisoning: serum iron levels
Hemochromatosis: serum ferritin, transferrin saturation, genetic testing, liver biopsy
total Zn content in the adult body
2.5g
Zn is present in…
more than 200 metalloenzymes as a cofactor regulating cell growth and immune function
Zn is absorbed in
small intestine
80% of Zn is in
red blood cells
20% of zin is in
plasma, bound to albumin
impaired taste and smell, hair loss, frequent infections, skin lesions, impaired wound healing
symptoms of Zn deficiency
ceruloplasmin is
the protein that binds copper
copper function
RBC formation and maintenance of normal brain function
detecting Cu toxicity
liver biopsy
disease of Cu toxicity
Wilson’s disease
Diagnostic golden-brown ring around the edge of the cornea
Kayser-Fleicher ring = copper toxicity
