Transdermal Flashcards
0
Q
Does the nitroglycerin transdermal system relieve acute attacks?
A
No, nitroglycerin transdermal systems are only indicated for prevention of angina pectoris.
1
Q
The drug is evenly distributed, can be cut in half, contains a release liner, and is released from the adhesive in which transdermal system
A
Adhesive matrix
2
Q
What’s the trade name for ranolazine?
A
Ranexa
3
Q
What type of matrix are contained in Minitran and Nitro-Dur?
A
Adhesive matrix
4
Q
How often is Minitran given?
A
Qday
5
Q
Which transdermal system can’t be cut in half and haas rate controlling membrane?
A
Reservoir
6
Q
How often should ranolazine (Ranexa) be given?
A
Bid
7
Q
How often should Nitro-Dur and Minitran be given?
A
Wear for 12 hours then take off for 12 hours
8
Q
What’s the term for painful intercourse?
A
Dyspareunia
9
Q
What’s the term for inflammation of the vagina of thinning and shrinking of tissues?
A
Atrophic vaginitis
10
Q
What’s the BBW for estradiol transdermal systems such as Menostar, Climara, Vivelle-Dot, Alora, and Minivelle?
A
Increased risk of CVD, dementia, and endometrial cancers
11
Q
Which estradiol transdermal patch is indicated for osteoporosis only?
A
Menostar
12
Q
Which type of matrix are the estradiol transdermal systems?
A
Adhesive
13
Q
Which are the strengths for Minivelle?
A
0.0375, 0.05, 0.075, 0.1 mg/24 hours
14
Q
Which estradiol transdermal comes in a strength of 0.014 mg/24 hours
A
Menostar
15
Q
How often is Climara given?
A
Qweek
16
Q
How often are Vivelle Dot and Alora given?
A
Twice weekly
17
Q
How often is Menostar given?
A
Qweekly 0.014 mg/24 hours
18
Q
What are the indications for estradiol transdermal systems?
A
- Vasomotor symptoms
- Vaginal atrophy
- Osteoporosis
19
Q
How often are Minivelle, Alora, and Vivelle-Dot given?
A
Twice weekly
20
Q
Which estradiol topical emulsion contains soybean oil?
A
Estrasorb
21
Q
How often is Estrasorb (estradiol) given?
A
2 packets every morning 0.05 mg/2 packets; place one packet on the leg for 3 minutes, one packet on right leg for 3 minutes, rub the excess on the buttocks
22
Q
What’s the trade for estradiol 0.021 mg/spray transdermal spray?
A
Evamist
23
Q
Where do you spray Evamist?
A
Spray on the inside of the arm
24
How often should Evamist be given?
One spray daily
25
Which estradiol products are indicated for vasomotor symptoms only?
1. Estrasorb-left and right leg then buttocks
2. Evamist-forearm
3. Divigel-upper thigh
26
How often is Divigel given?
Daily
27
What's the trade for ethinyl estradiol + norelgestromin?
Ortho Evra-given weekly-adhesive matrix-apply 1 patch for 3 weeks then go patch free for one week repeat
28
How often is Activella given?
Qday
29
What are the trade names for estradiol + norethindrone?
CombiPatch, Activella
30
What's the trade name for estradiol and levonorgestrel?
Climara Pro
31
What's the trade for the conjugated equine estrogens?
Premarin Vaginal Creams
32
What's the trade for the 10 mcg vaginal tablet?
Vagifem
33
What's the trade for the 0.1 mg/g vaginal cream?
Estrace
34
What's the maintenance dose for Estrace?
1-3x a week
35
What's the dosing interval for Femring?
0.05 and 0.1 mg/24 hours every three months
36
Which are indicated for VM, VA, and O?
Activella-comes in 0.5 mg/0.1 mg tablet as well as 1 mg/0.5 mg tablet
37
How often is CombiPatch given?
Twice weekly
38
How often is Activella given?
Qday
39
What's the trade for the 0.625 mg/g vaginal cream?
Premarin Vaginal Cream
40
What's the initial dose for Vagifem?
1 tablet qday for 2 weeks then a maintenance dose of 1 tablet twice weekly
41
Which are indicated for VA only?
Vagifem, Premarin Vaginal Cream
42
Which estradiol must be refrigerated?
CombiPatch
43
What are Climara Pro's indication?
Indicated for VM and O
44
What percent is estradiol topical gel?
0.1% in 0.25, 0.5, 1 gram packets of gel
45
What's the dosing interval for Estrace?
Initial: give daily for 2 weeks then after / weeks give half a dose daily daily for 2 weeks
Maintenance: 1-3x weeks
46
Which estradiol products contain alcohol USP?
Evamist, Divigel
47
How much testosterone do men produce daily?
5 mg/day
48
What are the synthetic derivatives of testosterone?
Anabolic steroids
49
What drugs do testosterone transdermal systems interact with?
They decrease anticoagulant and insulin requirements
50
What control level are anabolic steroids?
CIII
51
How often should testosterone transdermals be given?
All are given daily-Androderm, AndroGel, Testim, Fortesta, Axiron
52
What testosterone transdermal patch comes in strengths of 2 mg/24 hours and 4 mg/24 hours?
Androderm
53
Which testosterone transdermal is a reservoir patch?
Androderm
54
Which testosterone transdermal comes in 5 gram single dose packets? 50 mg testosterone= 5 mg absorbed
Testim
55
What single dose packet sizes does AndroGel come in?
2.5 grams, 5 gram= 25 mg, 50 mg testosterone-2.5 mg, 5 mg absorbed via the shoulder
56
What % metered dose pump does AndroGel come in?
1%, 1.62%
57
With a 1% AndroGel testosterone pump, how many milligrams are absorbed via the shoulder?
5 mg absorbed via the shoulder; 1 pump=12.5 mg x 4 pumps= 50 mg with 5 mg absorbed
58
What's the metered dose pump that includes alcohol USP used as a topical solution?
Axiron-give daily-ALL testosterone transdermals are DAILY
59
Which testosterone metered dose pump is applied as two pumps to each thigh to minimize secondary exposure?
Fortesta
60
How often is Kapvay given?
Bid (maintenance)
61
What is. Kapvay indicated for?
ADHD
62
How often is Catapres given?
Qweek it comes in 0.1, 0.2, 0.3 mg/24 hours
63
What is Catapres indicated for?
Hypertension
64
What strengths does Kapvay come in?
0.1 mg, 0.2 mg ER tablet
65
What's the precaution with fentanyl transdermal system?
All may be fatal to children so discard appropriately
66
How often is Duragesic given?
q72h
67
Which fentanyl transdermal is given for chronic pain?
Duragesic-note 12 hour onset
68
What strengths does fentanyl come in?
12.5, 25, 50, 75, 100 mcg/hr
69
How often is Actiq given?
q4h-Rub on side of cheek for 15 minutes
70
What's the trade for the transmucosal lozenge on a stick
Actiq
71
How often is Onsolis given?
q2h
72
How often is the sublingual fentanyl tablet given?
Abstral
73
What's the trade for the fentanyl nasal spray?
Lazanda-1 spray in 1 nostril
74
Which fentanyl product should be placed in a child resistant container?
Lazanda
75
What's the trade for the fentanyl but cal tablet?
Fentora
76
What's the trade for the fentanyl sublingual tablet?
Abstral given q2h
77
How long can a scopolamine patch be left on?
3 days-note: place behind ear for 4 hours
78
If a scopolamine patch is used for surgery, when should it be placed behind the ear?
The evening before surgery
79
What strength does scopolamine come in?
5 mcg/hr
80
What's the trade for scopolamine patch?
Transderm-Scop
81
Which transdermal patch is indicated for pain associated with post herpetic neuropathy?
Lidoderm-lidocaine
82
What's the trade for the 5 % lidocaine transdermal patch?
Lidoderm
83
How often and how long should Lidoderm be applied?
Apply up to 3 patches a day at the same time; put one on for 12 hours, then remove for 12 hours
84
What's the trade for zoster vaccine?
Zostavax
85
What's the trade for varicella vaccine?
Varivax
86
What are the indications for Neurontin?
1. PHN
| 2. Partial seizures
87
What are the indications for Lyrica?
1. PHN
2. Partial seizures
3. DPN
4. Fibromyalgia
88
What's the trade for mirabegron?
Myrbetriq
89
What's the trade for fesoteridone?
Toviaz
90
What's the trade for solifenacin?
Vesicant
91
What's the trade for darifenacin?
Enablex
92
What's the trade for the ER trospium capsule?
Sanctura XR
93
What's the trade for the IR trospium tablet?
Sanctura
94
How should trospium be taken?
Take on an empty stomach
95
What's the 10% topical oxybutynin gel?
Gelnique
96
What's the trade for the IR oxybutynin tablet?
Ditropan
97
What's the trade for the ER oxybutynin tablet?
Ditropan XL
98
What's the trade for the oxybutynin transdermal 3.9 mg/24 hours adhesive?
Oxytrol
99
How often should Oxytrol be given?
Twice weekly
100
Which class is Myrbetriq a part of?
Beta 3 agonist
101
Where is Gelnique applied?
The abdomen
102
How often is Gelnique given?
Qday
103
How often should Daytrana be given?
Qday
104
What's the indication for methylphenidate and what class?
ADHD; Controlled II
105
What strength does Daytrana come in?
10, 15, 20, 30 mg/9 hours
106
Where do you apply Daytrana and for how long?
Wear on the hip for 2 hours before needed, then take off 9 hours later.
107
What's the trade for granisetron?
Sancuso
108
How often should Sancuso be given?
Qweek-3.1 mg/24 hours
109
What are Zelapar and Eldepryl indicated for?
AntiParkinson's agent
110
What's the generic for Emsam, Eldepryl, and Zelapar?
Selegiline
111
What's the trade for ODT selegiline?
Zelapar
112
What's the indication for Emsam?
MAOI depressant
113
What's a drug interaction with Emsam?
Tyramine 9 mg, 12 mg; avoid pseudoephedrine and phenylephrine
114
What strengths does Emsam come in?
6, 9, 12 mg/24 hours
115
How often should Sancuso be given?
Qweek
116
How often should Emsam given?
Qday
117
What's the trade for aprepitant?
Emend
118
What's the trade for ondansetron?
Zofran
119
What's the trade for dolasetron?
Anzemet
120
What's the trade for palonosetron?
Aloxi
121
Which antiemetic is indicated for N/V patients receiving chemotherapy for 5 straight days?
Sancuso-granisetron
122
How soon should Sancuso be applied to upper arm before treatment?
24 hours and also taken off 24 hours after last treatment
123
What's the trade for galantamine?
Razadyne
124
What's the trade for donepezil?
Aricept
125
What's the trade for Exelon?
rivastigmine?
126
Where should Exelon Patch be applied?
In the middle of the back
127
How often should Exelon Patch be applied?
Qday; it comes in strengths of 4.6,9.5/24 hours
128
What's the dosing interval for Exelon Patch?
4.6 mg x 1 month, then increase to 9.5 mg as maintenance dose
129
How often should Butrans be given?
Weekly
130
What's the trade for parenteral buprenorphine?
Buprenex
131
What's the sublingual buprenorphine tablet?
buprenorphine
132
What's the indication for Buprenex?
Addiction
133
What's the trade for diclofenac epolamine?
Flector Patch
134
How often should Flector Patch be given?
Bid
135
Which COX enzyme does Flector Patch inhibit?
COX-2
136
What are the indications for Flector Patch?
1. Strains-stretched muscle
| 2. Sprains-stretched ligaments
137
What's a drug interaction with Flector Patch?
Aspirin
138
What's the trade for galantamine?
Razadyne
139
How often should Butrans be given?
Qweek comes in 5, 10, 20 mcg/hour
140
Which strength of buprenorphine are used in opioid tolerant patients?
10 and 20 mcg/hour
141
What's the dosing interval for Exelon Patch?
4.6 mg x 1 month; then increase to 9.5 mg as maintenance dose
142
What category is Zyban?
Aminoketone antidepressant
143
What's the dosing interval for Zyban?
Take 1 tablet for 3 days then bid for 12 weeks
144
How often should Zyban be started before trying to quit?
Give one week to reach therapeutic levels
145
What's the dosing interval for Chantix?
Take 0.5 mg qday for 3 days, then 0.5 mg bid for 4 days, then 1 mg bid for 12 weeks
146
What's Chantix mechanism of action?
Nicotine receptor agonist; varenicline binds to its receptor and produces nicotine-like effects and inhibits nicotine
147
What's the DI for Nicoderm CQ?
Daily
148
What are the strengths of Nicoderm CQ?
7 mg, 14 mg, 21 mg/24 hour adhesive matrix
149
What's the DI for Nicoderm CQ based off of?
Cigarettes smoked per day
>10 cigarettes: 21 mg-6 weeks, 14 mg and 7 mg-2 weeks
<10 cigarettes: 14 mg-6 weeks, 7 mg-2 weeks
150
Where should Nicoderm CQ be applied?
Upper part of arm; remove after 24 hours (do not reuse this site for 7 days) and apply new patch to different site-fold patch in half to discard
151
What's the max daily dose for Nicotrol Inhaler?
Max daily dose/day 16 cartridges= 4 mg cartridge; contains enough nicotine for 20 minutes of active puffing; transmucosal so do. to inhale into lungs
152
Trade for cromolyn sodium?
Nasalcrom
153
Class for Nasalcrom?
Mast Cell Stabilizers
154
Trade for desmopessin acetate?
DDAVP, Stimate
155
Which class is DDAVP and Stimate?
desmopessin acetate
156
Trade for ipratropium bromide?
Atrovent Nasal Spray
157
Which class is Atrovent Nasal spray?
Anticholinergics
158
Which class is Astelin, Astepro?
Antihistamines
159
Which condition are Miacalcin, Fortical indicated for?
calcitonin
160
Which class is Omnaris, Nasonex, Veramyst, Flonase, Rhinocort Aqua, Nasacort AQ?
Corticosteroids
161
What's the trade for triamcinolone?
Nasacort AQ
162
Trade for ciclesonide?
Alvesco
163
Term for rate of diffusion through the skin?
Flux
164
How do you apply a transdermal patch?
Place patch in the middle of the palm and press down on area firmly for 10 seconds to get contact with edges
165
How often should Minitran or Nitro-Dur be given?
Qday or daily
166
Can you take Minitran or Nitro-Dur for an acute attack?
No, it's for prevention of angina pectoris
167
What's the rate of Minitran?
0.1 mg/hr
168
How long do you wear Minitran?
12 hours then give 12 hour break
169
Side effect of Minitran?
Headache
170
How often should Ranexa be given?
Twice daily; comes in 500 mg, 1000 mg strength
171
What category is Ranexa?
Vasodilator
172
Name of the estrogen hormone indicated for hormone replacement therapy in post-menopausal women?
Estradiol
173
Which estradiol transdermal system is indicated for osteoporosis only?
Menostar
174
What BBW do estradiol transdermals have in pre-menopausal women?
Endometrial cancer
175
What BBW do estradiol transdermals have in post-menopausal women?
CVD and dementia
176
Strengths of Climara?
0. 025 mg/24 hour
0. 0375 mg/24 hour
0. 05 mg/24 hour
0. 06 mg/24 hour
0. 075 mg/24 hour
0. 1 mg/24 hour
177
Strengths of Vivelle-Dot?
0. 025 mg/hr
0. 0375 mg/hr
0. 05 mg/hr
0. 075 mg/hr
0. 1 mg/24 hour
Basically one less than Climara...there's no 0.06 mg/hr
178
Strengths for Alora?
0. 025 mg/24 hour
0. 05 mg/24 hour
0. 075 mg/24 hour
0. 1 mg/24 hour
179
Strength of Menostar?
0.014 mg/24 hour
180
When is Estrasorb given?
In the morning
181
When is Evamist given?
Daily or qday
182
What is Estrasorb indicated for?
Vasomotor symptoms only
183
Which estradiol should you not use in allergic to peanuts?
Estrasorb
184
How often should Evamist be given?
Daily
185
What's the indication for Evamist?
Vasomotor symptoms
186
Strength of Evamist?
0.021 mg/spray
187
Indications for CombiPatch?
VM, VA
188
Dosing interval for CombiPatch?
Twice weekly
189
Dosing interval for Climara Pro?
Qweek
190
Indication for Climara Pro?
VM, O
191
Term for a synthetic progesterone?
Progestin
192
CombiPatch should it be kept at room temp or refrigerated?
Refrigerated
193
Max pieces of Nicolette DS?
20
194
Max pieces of Nicorette?
30 pieces
195
Precaution with Nicorette?
Do not swallow
196
How is Nicorette absorbed?
Buccal mucosa
197
The rate and extent of Nicotine is dependent on?
pH dependent
198
What should be avoided when taking Nicorette?
Coffee, soft drinks, fruit juices
199
How many times should you chew Nicorette?
15 times until peppery taste or tingling subsides then place between cheek and gym until taste is gone....repeat for 30 minutes
200
Which nicotine lozenge strength must be taken within 30 minutes of waking?
4 mg
201
Which nicotine lozenge should be taken after 30 minutes of waking?
2 mg
202
What's the dosing interval for nicotine lozenges?
Take 1 lozenge either 2 or 4 mg every 1 to 2 hours for 6 weeks then q2-4 hours for 3 weeks then q4-q8 hours every 3 weeks
203
Nicotrol Inhaler contain nicotine for how many minutes of active puffing?
20 minutes
204
Nicotine lozenge is dose dependent on?
Time to first cigarette
205
What type of system is Nicoderm CQ?
Adhesive matrix transdermal system
206
Where should Nicoderm CQ be applied?
Apply daily to clean, hairless, dry area on upper outer part of arm
207
Is a person smokes less than 20 cigarettes a day, what's the DI?
14 mg for 6 weeks
| 7 mg for 2 weeks
208
Is a person smokes more than 20 cigarettes a day, what's the DI?
21 mg for 6 weeks, 14 mg for 2 weeks, 7 mg for 2 weeks
209
Category for Lidoderm?
Local anesthetics
210
Does Lidoderm contain percutaneous absorption enhancer?
No; don't want it to go into systemic circulation
211
Lidoderm treats?
Pain from PHN, herpes zoster, varicella virus
212
What age group is Zostavax indicated for?
Patients 50 and older
213
How often should Oxytrol be taken?
Twice weekly comes in 3.9 mg/24 adhesive matrix
214
What's the TC for Oxytrol?
Antispasmodic or Anticholinergic
215
How often should Gelnique be given?
Daily
216
How should Sanctura and Sanctura XR be taken?
On an empty stomach
217
How often should Emsam be given?
Daily
218
What's the category for Emsam?
MAOI antidepressant
219
What's the trade of the only transdermal patch indicated for depression?
Emsam
220
Trade for selegiline capsule?
Eldepryl
221
Trade for selegiline ODT?
Zelapar
222
What's the trade for selegiline capsule?
Eldepryl
223
What are Eldepryl and Zelapar indicated for?
AntiParkinson's
224
What adhesive matrix strengths does Ensam come in?
6 mg/24 hr, 9 mg/24 hr, 12 mg/24 hr
225
What's the category for Emsam?
MAOI antidepressants
226
Patient counseling for Sancuso?
Avoid photo toxic reaction by avoiding sun to area patch was applied for 10 days following removal.
227
How often should Exelon Patch be given?
Daily
228
What's the strength for Exelon patch?
4.6 mg/24 hr; 9.5 mg/24 hr
229
What's the category for Exelon patch?
Cholinesterase inhibitors
230
How does Exelon Patch work?
Increases Acetylcholine levels
231
What dose do patients start on with Exelon patch?
4.6 mg initial for a thought then a maintenance of 9.5 mg per dose
232
Where should Exelon Patch be applied?
Middle of the back
233
What's the category for Razadyne and Aricept?
Cholinesterase inhibitors
234
What's the category for Butrans?
Opioid analgesics give it weekly do not reuse same site for 3 weeks
235
Trade for buprenorphine adhesive matrix?
Butrans in strengths of 5 mcg/hr, 10 mcg/hr, 20 mcg/hr
