Transplant Flashcards
(13 cards)
What are the side effects of CNis?
- Nephrotoxicity
- Neurotoxicity
- HT
- Hyperlipidaemia
- Hyperglycaemia (T > CsA)
- Hypomagnasaemia
- Hyperkalaemia
- Hirsuitism (CsA) / Hair loss (T)
- Gingival hyperplasia (CsA)
- Diarrhoea
Cyclosporin
- Think: Hairy, Gummy & Gouty
- Hirsuitism
- Gingival hyperplasia
- Hyperuricaemia
Tacrolimus
- Think: Bald, BSLs & Bowels
- Allopecia
- Hyperglycaemia
- Diarrhoea
What are the complications of both types of calcineurin inhibitors?
Headache
Tremor
Nephrotoxicity
Hypomagnasaemia
Hyperkalaemia
What are the unique side effects of cyclosporin?
Think of cyclo the chimp as King of the Jungle
Hirsuitism
Hypertension
Hyperlipidaemia
Gout
Gingival hyperplasia
What are the unique side effects of tacrolimus?
Alopecia
Diabates
Think of tacro the tortise, the king of the sea
What are the side effects of CNis?
- Nephrotoxicity
- Neurotoxicity
- Hypomagnasaemia
- Hyperkalaemia
Cyclosporin
- Hirsuitism
- HT
- Hyperlipidaemia
- Gout
- Gingival Hyperplasia
Tacrolimus
- Allopecia
- Hyperglycaemia
What are the overall complications of immunosupression?
- Cancer - SCC / BCC, lymphoma
- Infection
What are the metabolic complications of IS?
- Diabetes (tacro, steroids)
- HT (cyclo, steroids)
- Hyperlipidaemia (cyclo, MTORi, steroids)
- Weight gain (steroids, MTORi)
What are the side effects of mycophenolate?
GI symptoms
Cytopenias
Hepatitis
Pancreatitis
If someone is on mycophenolate with GI symptoms…
- what do you need to rule out?
- how could you improve them?
Rule out infection esp CMV colitis
If GI symptoms are due to MMF:
- Reduce the dose of MMF
- Break up doses of MMF
- Change mycophenolate mofetil –> mycophenolate sodium / myfortic / mycophenolic acid (absorbed more distally & less GI toxicity
What are the side effects of azathioprine?
Myelosupression
Hepatitis
Pancreatitis
What medication shouldn’t you take with azathioprine?
allopurinol
CMV and HSV prophylaxis
oral and IV
Remember G = C
ValGanciclovir (oral) / Ganciclovir (IV) is for CMV (also covers HSV/VZV)
Valaciciclovir (oral) / Aciclovir (IV) is for HSV / VZV
Barries to transplantation
