Transplantation Immunology Flashcards Preview

Immunology, Rheumatology, Dermatology > Transplantation Immunology > Flashcards

Flashcards in Transplantation Immunology Deck (15)
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1

CD28

-Expressed constituitively on T-Cells

-Binds with CD80

2

Syngeneic Graft

-Genetically Identical

-Either Isograft or autograft

3

Indirect Alloimmune recognition

Just peptide

4

Time frame for acute graft rejection?

2-21 days

5

Allogeneic Graft

-Allelic different graft

- Xeno or Allo graft

6

Three Stages of Graft Acceptance?

 

  1. Revascularization (d3-7)
  2. Heal (d7-10)
  3. Resolve (d12-14)

7

Two stages of Second Set Rejection

  1. Cellular infiltration (d2-4)
  2. Thromob/Necro (d5-6)

8

Four main immunosuppression agents

  1. Steroids (Prednisone)
  2. Adjunctive (Imuran,Cellcept,Rapamune)
  3. Calcineurin Inhib (Cyclosporine,Tacrolimus)
  4. Anti-lymphos(Campath,Thymoglogulin,Zenapax)

Want to avoid initial T-cell recognition; espeically IL-2

9

Direct Alloimmune recognition

Just MHC

10

Three stages of first set rejection

  1. Revascularize (d3-7)
  2. Inflamm (d7-10)
  3. Thrombo/Necro (d12-14)

11

CD40L

- Co-stim found on T-helpers

- Binds with CD40 on B-cells for G.C.s, Class-Switch and Delayed type hypersensitivity

12

Four ways to deal with ab mediated reaction

  1. Plasmapheresis
  2. IV Ig
  3. Rituximab (against CD20 on B-cells)
  4. Bortezomib (block plasma ab production)

13

Semi-Indirect Alloimmune recognition

MHC and Peptide recognition

14

Tmeframe for Chronic graft rejection?

Around 3months

15

CD80

-Gets upregulated in cells during inflammation

-Binds with T-cell's CD28