Cole's Immunology Flashcards Preview

Immunology, Rheumatology, Dermatology > Cole's Immunology > Flashcards

Flashcards in Cole's Immunology Deck (26)
Loading flashcards...
1

Three types of PRRs

  1. Signaling (TLRs)
  2. Cytosolic (NLR)
  3. Endocytic/Membrane-bound (C-type lectins, Sugars, Lipids, Complement binders)

2

Two steps for C3b opsonization

  1. Bind to CR1
  2. Get a second signal (like C5a)

3

Graves Disease

- G&C Type II

- Hyperthyroidism

- abs against TSH receptor

4

KIRS and Lectinlike CD94/NKG

Two types of receptors that make sure NK cells don't kill normal cells.

5

What complement protein is the highest amount in the blood?

C3

6

Acute Rhuematic Fever

- Group A Strep & M-heart protein have similar ganglioside

- Body attacks and causes fever

7

What are the two C3 convertases?

  1. C4b2a for classical and MBL
  2. C3bBb for alternative

8

What are the three Complement pathways?

  1. Classical
  2. MB-Lectin
  3. Alternative

9

Coxsackie B4 and Cytomega virus share a ganglioside with ___ cells, and so they cause ____

islet cells, diabetes

10

CD19

Part of B-Cell receptor

11

What are the serine proteases for the MBL pathway?

- MASP-1 and MASP-2

- MASP-2 cleaves C4 and C2

12

Five Immuno-Escaping Mechanisms

  1. Downreg MHCs
  2. Alter/Swallows ab's
  3. Tolerize cells (remove co-stim)
  4. Hijack Immuno regs (IL-10)
  5. Physical barrier (collagen)

13

What are the top 3 Complement proteins that mediate inflammation?

  1. C3A
  2. C5A
  3. c4a does it too, but not as good

14

Mouse Polyoma, Sarcoma, and Hepatitisi B are manifestations which resulted from a ____-induced TSA with varied antigens

Virally

15

Methylcholanthrene

A Chemical Inducing TSA, leads to varied antigens

16

Myasthenia Gravis

- G&C Type II

- Ach receptor blocked by antibody

17

Guillane Barre

-Uses Both Abs and T-cells to attack nerve

- Campylobacter shares nerve ganglioside

-Causes Paralysis

18

Four main immunoprivleged sites

  1. Brain
  2. Testis
  3. Uterus
  4. Eyes

19

Three approaches for cancer treatment

  1. CARS, T-Targets
  2. Abs, W/w/o toxin/radionuc
  3. Lymphos from own tumor get activated with GM-CSF or Co-stim gene

20

What are the serine proteases for Alternative pathway?

-B and D

- Uses Properdin

- Directly interact with pathogen surfaces

21

Gamma-delta T-cell

- Doesn't have typical alpha beta chain

- Recognizes MICs (cells stress markers)

- Helps kills AND replace cells

22

CD16

Macrophage/NK ADCC receptor (Not MHC-restricted)

23

Negative Selection

Removal of Auto-reactive 

24

MAGE-1, MUC-1, PSA, p53

Silent cellular genes which create proteins that are TSAs because normal cells aren't expected to produce them.

25

B7

Co-Stim found on APCs, interacts with CD28 on T-Cell to activate and promote class-switch

26

3 Types of Tumor-Specific Antigens

  1. Chemically induced, result in Varied unique antigens
  2. Virally induced, result in Shared antigens
  3. Silent genes, not expressed by normal cells