Immunodeficiencies Flashcards Preview

Immunology, Rheumatology, Dermatology > Immunodeficiencies > Flashcards

Flashcards in Immunodeficiencies Deck (16)
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1

Chediak-Higashi Syndrome, 4F's

-Dark Skin
- Low NK, Low CTL
- Defect in forming granules
- Giant Lysosomes are created

2

Three functions of immune system

1. Defense
2. Homeostasis
3. Surveilllance

3

Consequences of leukocyte adhesion deficiencies?

1. Leukos can't leave and create lesions
Seen in gums or umbilical cord (type 1)
Seen with selectins getting ruined (type 2)

4

Presentation of late defects in complement

- Neisserial attacks
- Gram-Negative infections that need to be MAC'D

5

Hyper homeostatic function leads to:

Autoimmune disease

6

Presentation of early defects in complement: (C1q, C4, C2)

-Staph infections
- Lupus
- Scleroderma

7

Dihydrorhodamine Test

Measure ability of white cells to be stimulated

8

DiGeorge Syndrome

- Caused by decrease in T-cells
- Hypocalcemia
- Viruses and Fungi are big risks

9

Hypo defense leads to:

Immunodeficiency; 65% due to antibody

10

Gel-Coombs 4 Types

1. IgE
2. Cytotoxic
3. Ag/Ab and Complement
4. Delayed Hypersensitivity

11

Secondary Immunodeficiency

External defects like Diabetes, AIDS, cystic fibrosis, Age, Trauma, Cancer, Drugs

12

C1 inhibitor deficiency presentation:

-Hereditary Angioedema

13

Primary immunodeficiency

Defects in innate/adaptive system

14

Hyper defense leads to:

Allergy

15

Three "T's" for Molecular Biology

1. Transduction
2. Transcription
3. Translation

16

Four Key Defects in immunodeficiency (Chronological)

1. Granulomatous Disease (hematopo defect)
2. SCID (Lym progen defect)
3. DiGeorge (T-defect)
4. XLA (B-defect)`