Trypanosoma Cruzi Flashcards Preview

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Flashcards in Trypanosoma Cruzi Deck (25):
1

order

kinetoplastorida

2

common name

chaga's disease

3

hosts

dogs, cats, humans

4

what are the reservoir hosts?

many animals, wild and domestic

5

what are required for growth?

vectors

6

identification

elongated
spindle or leaf shaped
nucleus near middle
flagella
kinetoplast
undulating membrane

7

size?

20 micrometers

8

what end is pointed?

posterior end

9

how many flagellum are on the posterior end?

one

10

what end has a free flagellum?

anterior tip

11

site of infection

blood- cardiac and smooth muscle

12

how is this parasite transmitted?

biting insects

13

life cycle

and infected triatomine insect vector takes a blood meal and releases trypomastigotes in its feces near the bite wound. trypomastigotes enter the host wound. Trypomastigotes invade cells, where they differentiate and invade the circulation as blood stream trypomastigotes. Trypomastigotes infect cells and transform into amastigotes.

14

who are the common triatomine vector species?

belong to the genera Triatoma, Rhodnius, and Panstrongylus

15

do blood stream trypomastigotes replicate?

no- replication resumes only when the parasite enters another cell or are ingested by another vector

16

how does the kissing bug get infected?

by feeding on human or animal blood that contains circulating parasites. the ingested trypomastigotes transform into epimastigotes in the midgut. the parasites multiply and differentiate in the midgut. Turn into infective metacyclic trypomastigotes in the hind gut

17

how do trypanosomes enter the body?

oral, nasal, conjuctival mucosae or infected bug feces. Also through, placenta, blood transfusion, organ transplant or when dogs drink water with infected bugs

18

pathogenesis

pathology in heart muscle - highly pathogenic
3 stages of disease: acute, latent, and chronic

19

who is most susceptible to Chagas?

puppies and kittens

20

clinical signs

cardiac disease, pale mucous, membranes, lethargy, ascites, hepatomegaly (enlarged liver), splenomegaly, tachyarrhythmia, lymphadenopathy

21

diagnosis

blood smear
xenodiagnosis or serological tests

22

treatment

no treatment known
possibly insecticides

23

what is kinetoplast?

modified mitochondria

24

what is undulating membrane

external flagellum attached to cell body

25

what are the various forms of trypanosomatids

trypomastigote, amastigote, epimastigote, promastigote