Tuberculosis Flashcards Preview

Med Spec (Infectious Diseases) > Tuberculosis > Flashcards

Flashcards in Tuberculosis Deck (36)
Loading flashcards...
1

What stain is used to test for acid fast bacilli?

Ziehl-Neilson stain

2

In those with suspected TB, how are samples for microscopy and culture taking in patients who cannot produce sputum?

Bronchoscopy/bronchoalveolar lavage

3

What will histology of a lung biopsy of someone with TB show?

Caseating granulomas and acid fast bacilli

4

What is the standard treatment regimen for active TB?

2 months of rifampicin, isoniazid, pyrizinamide and ethambutol; 4 months of rifampicin and isoniazid

5

What is a fairly common side effect of many anti-TB drugs, and what is the best blood test to monitor for it?

Hepatitis- monitor LFTs

6

What are the two tests that can be used to screen for evidence of current/previous infection with TB?

Mantoux test, interferon gamma release blood tests

7

If the screening tests for TB are positive, what is the next investigation used to assess for evidence of active TB?

CXR

8

Describe how a Mantoux test can often cause false positives?

Those who have had the BCG

9

Describe how a Mantoux test can often cause false negatives?

Those with miliary TB

10

What are some common CXR findings of TB?

Upper lobe shadowing and cavitation; mediastinal lymph node enlargement

11

What is the most important microbiological test for TB?

Sputum sample for acid-fast bacilli and culture

12

How many samples of sputum should be taken for testing for acid-fast bacilli?

3 morning samples

13

On a CXR, the presence of what suggests primary TB?

Ghon complex, a ghon focus and hilar lymphadenopathy

14

On a CXR, the presence of what suggests secondary TB?

A fibrosing and cavitating apical lesion

15

TB most commonly presents as a history of systemic disturbance lasting how long?

Weeks-months (subacute)

16

Name the most common systemic features of TB?

Weight loss, fever, malaise and night sweats

17

What are the most common respiratory features of TB?

Cough and haemoptysis

18

What organism is responsible for the vast majority of cases of TB?

Mycoplasma tuberculosis

19

M. bovis is a rare cause of TB- how is it acquired?

Drinking infected cow's milk

20

What is meant by the term miliary TB?

Active TB which is disseminated around the body via haematological spread

21

Multi-drug resistant TB describes TB which is resistant to which antibiotics?

Rifampicin and isoniazid

22

What are the chances that latent TB will progress to active TB?

5% risk of progression to active disease within two years of infection; 5% lifetime risk of reactivation thereafter

23

Where in the world is the incidence of TB highest?

Asia and sub-Saharan Africa

24

Name some high risk groups for TB infection?

Birth in high incidence countries, immunosuppresion, overcrowding/homelessness

25

What vaccination is used to try to prevent TB?

BCG

26

What are the two treatment options for latent TB?

6 months of isoniazid OR 3 months of isoniazid and rifampicin

27

How is TB spread?

Respiratory droplets

28

What is the key histological feature of TB and what is this known as?

Caseating granulomas, known as a Gohn focus

29

What type of hypersensitivity reaction is TB?

Type IV

30

Which anti-TB drug is a liver enzyme inducer?

Rifampicin