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Flashcards in Tumor Suppressors Deck (15)
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1

APC

negative regulator of beta-catenin/WNT pathway; colorectal cancer (a/w FAP)

2

BRCA1/BRCA2

BRCA1/2 proteins; breast, ovarian, prostate, pancreatic cancers

3

CDKN2A

p16; blocks G1>S phase; many cancers

4

DCC

Deleted in Colorectal Cancer

5

SMAD4 (DPC4)

Deleted in Pancreatic Cancer; pancreatic and colorectal cancer

6

MEN1

Menin; MEN type 1

7

NF1

neurofibromin (Ras GTPase activating protein); NF type 1

8

NF2

Merlin (schwannomin) protein; NF type 2

9

PTEN

negative regulator of P13K/AKT path; Prostate, breasT, ENdometrial cancers

10

RB1

inhibits EF2; blocks G1>S phase; Retinoblastoma, osteosarcoma (Bone cancer)

11

TP53

p53, activates p21, blocks G1>S phase; most cancers, Li-Fraumeni (multiple malignancies at early age, AKA SBLA syndrome for Sarcoma, Breast, Leukemia, Adrenal gland)

12

TSC1

Hamartin protein; tuberous sclerosis

13

TSC2

tuberin (2berin); tuberous sclerosis

14

VHL

inhibits hypoxia-inducible factor 1a; Von Hippel-Lindau

15

WT1

urogenital development TF; Wilms Tumor (nephroblastoma)