Oncogenes Flashcards Preview

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Flashcards in Oncogenes Deck (12)
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1

ALK

receptor TK; lung adenoCA

2

HER2/Neu

receptor TK; breast and gastric CA

3

RET

REceptor Tyrosine kinase; MEN 2A and 2B, medullary and papillary thyroid CA, pheochromocytoma

4

BCR-ABL

non-receptor TK; CML, ALL

5

JAK2

non-receptor TK; myeloproliferative neoplasms

6

BRAF

serine/threonine kinase; melanoma, non-Hodgkin lymphoma, papillary thyroid CA, HCL

7

c-KIT

CytoKIne receptor; GIST, mastocytosis

8

c-MYC

TF; Burkitt

9

MYCL1

TF; Lung cancer

10

MYCN (N-myc)

TF; Neuroblastoma

11

KRAS

RAS GTPase; colorectal, lung, pancreatic cancers

12

BCL-2

antiapoptotic molecule; follicular and DLBCL