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Flashcards in Tumors or GI tract Deck (56)
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1
Q

What is the 4th most common site of D/C tumors

A

Oral tumors

2
Q

Oral tumors occur more in what species and sex

A

Dog, Male

3
Q

Oral tumor presenting complaint

A

middle aged -> older
visible mass: difficulty eating, oral bleeding, halitosis
Recent dental hx

4
Q

Genetic predisposition to oral tumors

A

Boxers, GSD, Goldens, Cockers, Mini poodle, German SHP, Gordon Setter, Chows, Weimaraner

5
Q

Oral tumor differential diagnosis - Dog

A

Melanoma. SCC. Fibrosarcoma.
OSA.
Odontogenic tumors (epulides)

6
Q

Oral tumor differential diagnosis - Cat

A

SCC. Fibrosarcoma.

7
Q

Oral tumor Work up & Staging

A
Cytology - ineffective
Biopsy
Radiographs - low yield
Lnn Staging w/ FNA
3 view thoracic met check (ALL)
8
Q

Oral tumor biopsies

A

proliferative mass - shave biopsy

Non proliferative mass - incisional

9
Q

Oral Malignant melanoma

A

Black or melanotic melanoma
80% mets (high malignancy - lungs/lnn)
thorough staging! Biopsy

10
Q

Oral Malignant melanoma biggest failure

A

systemic mets

11
Q

Oral SCC

A

locally invasive, low mets.

Cats: paraneoplastic hyperCa. Sublingual site preferred

12
Q

Oral Fibrosarcoma

A

Young, large breeds

very invasive but looks benign - don’t believe fibroma histopath.

13
Q

Oral Fibrosarcoma biggest failure

A

recurrent disease: didn’t resect it all

14
Q

Odontogenic tumor origin

A

periodontal ligament

15
Q

3 types of odontogenic tumors

A

Acanthomatous ameloblastoma
Peripheral odontogenic fibroma
Feline inductive odontogenic tumor

16
Q

Acanthomatous ameloblastoma

A
locally invasive (bone) no mets
very aggressive sx required - 1 cm margins
Shetland and sheep dogs, rare in cats
17
Q

Peripheral odontogenic fibroma

A

slow, benign - no bone involvement
common in dogs
cryotherapy

18
Q

Feline Inductive odontogenic tumor

A
young cats (8-18m)
locally invasive
19
Q

Treatment of oral tumors

A

Aggressive Sx excision - almost all have bone involvement

2cm margins for malignancies

20
Q

Radiation and chemo or oral tumors

A

Adjunct RT - melanoma!, SCC, Acanthomatous ameloblastoma, FSA.
Chemo not commonly used

21
Q

Oral positive prognostic indicators

A

Smaller tumor
Rostral location
Complete resection
No evidence of preop mets

22
Q

Esophageal tumors

A

Rare.
Older animals
S. lupi - sarcomas
esophageal obstruction, stricture, 2˚ aspiration pneumonia

23
Q

Differential diagnosis of esophageal tumors

A

SCC

Leiomyosarcoma

24
Q

feline esophageal SCC tumor

A

females.

Middle 1/3rd, caudal to thoracic inlet

25
Q

Esophageal work up and staging

A

Imagining - megaesophageus?
Esophagoscopy (GS)- biopsy
fecal

26
Q

Esophageal tumor therapy

A

Surgery!
best for low grade leiomyosarcomas
RT - limited
Palliation - feeding tube

27
Q

Esophageal tumor prognosis

A

Very poor

benign/low grade/LSA can be okay

28
Q

Drug to resolve S. lupi infection

A

Dormectin

29
Q

Gastric tumors

A

uncommon
males
chronic gastritis, helicobacter
Asymptomatic until blocking outflow - anorexia/hematemesis

30
Q

Gastric tumor genetic predilection

A

Belgian shepherd, chows

Benign - beagles

31
Q

Gastric Tumor dog differentials

A

Big 2
Adenocarcinoma (70-80%)
Leiomyosarcoma

32
Q

Gastric tumor Cat differentials

A

Big 1

Lymphoma

33
Q

Cat systemic status w/ gastric lymphoma

A

negative FeLV

possible concurrent LSA in small intestine

34
Q

Gastric ademocarcinoma

A

predictable - pyloric antrum/lesser curvature
Scirrhous (leather)
High met rate (anywhere)
deeply ulcerative

35
Q

Gastric work up and staging

A

Non specific lab
Abdominal US (decreased motility)
ENDOSCOPY - biopsy

36
Q

Gastric leiomyomas

A

well circumscribed, submucosal mass

cardiac location - benign

37
Q

Gastric tumor Treatment

A

Surgical excision
partial gastrectomy
gastroduodenostomy/jejunostomy (bilroth 1 or 2) - high morbidity

38
Q

Gastric tumor prognosis

A

surgical excision, tumor type/grade, mets.

39
Q

ACA Gastric tumor prognosis

A

poor - majority dead in 6m

40
Q

LSA Gastric tumor prognosis

A

Doesn’t respond to chemo,

resect and chemo might not be needed

41
Q

Leiomyosarcoma Gastric tumor prognosis

A

12-21m

Cured with aggressive surgery

42
Q

Intestinal tumors

A

older animals, same presentation as gastric tumors

43
Q

Intestinal tumor Dog

A

uncommon
Large intestine!
Collie, GSD, male

44
Q

Intestinal tumor cat

A

uncommon

Small intestine!

45
Q

Intestinal tumor work up/staging

A

similar to gastric -
Goal: rule out LSA (no sx tx)
endoscopy (understand limits)
US guided FNA/cytology

46
Q

Intestinal tumor differential diagnosis dog

A

Big 3
LSA > ACA > Leiomyosarcoma
GIST

47
Q

Intestinal Tumor differential diagnosis cat

A

Big 3
LSA, ACA, MCT
no order

48
Q

Intestinal tumor treatment

A

Exploratory laparotomy - R&A
except LSA
4-8cm margins
assess mesenteric and regional lnn

49
Q

LSA intestinal tumor DOG

A

T cell, multifocal
not good remission or survival
Neg prog. factors: Failed to achieve remission

50
Q

LSA intestinal Tumor CAT

A

responds well to chemo

prognostic factor: response to tx

51
Q

ACA intestinal tumor dog

A

44% met rate - stage!

female neg prognosis?

52
Q

ACA intestinal tumor cat

A

72% mets on dx

neg prognostic: histo subtype and mets

53
Q

MCT intestinal tumor dog

A

100% mortality in 2m.
100% met rate.
BAD

54
Q

MCT intestinal tumor cat

A

poor - euthanize/death

*solitary MCT w/o mets have good survival

55
Q

Leiomyosarcoma intestinal tumor

A

old data.
8m MST dogs
cat - very uncommon

56
Q

Gastrointestinal Stromal Tumor (GISTs)

A

IHC can differentiate from leiomyosarcoma
from cells of cajal (GI pacemaker)
express c-kit
predilection for cecum
die from septic peritonitis (ruptured mass)