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Flashcards in Tumour Deck (329)
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301

 

What is a Bence Jones Protein?

 

Light chain immonuglobulin found in multiple myeloma.

302

What kind of chondrosarc does enchondrama change into?

low grade chondrosarcoma

303

 

Lifetime risk of malignant transformation for Maffucis?

 

100%

304

Name the 3 manifestations of eosinophilic granuloma and their characteristics

Eosinophilic granuloma

  • Single self-limited lesion in younger patients

Hand-Schuller-Christian disease (HSC)

  • chronic, disseminated form with bone and visceral lesions

Letterer-Siwe Disease

  • Fatal form that occurs in young kids

Can be Monoostotic or Polyostotic

305

 

What tumor shows predilection for the distribution shown in this figure?

 

Lymphoma

306

Recurrence rate of GCT of tendon sheath after marginal excision?

5-50%

307

Treatment for neurofibrosarcoma (malignant peripheral nerve sheath tumour)?

What must you specifically do?

Wide resection

Must resect the entire affected nerve

308

Name the syndromes associted with the spectrum of Langerhans cell histiocytosis

Eosinophilic Granuloma

  • Self-limited in younger patients

Hand-Schuller-Christian Disease

  • Chronic, disseminated form

Lettere-Siwe Disease

  • Fatal for in young kids

309

Do osteochondroma transform into high or low grade chondrosarcoma?

Low grade

310

Which primary can have mets distal to knee and elbow?

Lung

311

Name 1 poor prognostic factor for parosteal osteosarcoma

de-differentiation

312

Indicatios for surgical resection in osteoid osteoma

painful scoliosis

Too close to vital strucures for radiofrequency ablation (neural elements, skin)

313

NOF can be associated with what other tumour

ABC

314

In operative management of fibrous dysplasia, what should you never use

Autograft

It will rapidly be turned into fibrous dysplastic woven bone

315

Benign aggressive lesions? (3)

GCT, ABC, osteoblastoma

316

Seven questions for evaluating bone lesion on x-ray? 

(as per Toronto group)

1.  where is it?

2. how big is it?

3. What is it doing to bone? (destructive? geographic? permeative?etc.)

4.  what is bone doing to it? (sclerosis? periosteal rxn?)

5.  matrix?

6. cortex? (eroded? preserved? neocortex? endosteum?)

7.  soft tissue mass?

317

Which soft tissue sarcomas need chemo?

RSSD

Rhabdomyosarcoma

Synovial sarcoma

Soft-tissue Ewings

de-differentiated chondrosarc

HOWEVER THIS IS CONTROVERSIAL

SAFE ANSWER FOR TREATMENT OF SOFT TISSUE SARCOMA IS WIDE RESECTIO + RADIATION

318

Treatment of this pathologic fracture?

Sling for comfort

Nonop of pathologic fractures through UBC, unless they are in a weight bearing zone (proximal femur)

319

Which way do pedunculated osteochondraom lesions point?

Away from the joint

320

3 poor prognostic indicators for soft tissue sarcoma?

High grade

size >5cm

tumour location below deep fascia

321

how often is ABC associated with another tumour?

30% of the time

322

Synovial sarcoma genetics

t(X;18)

Forms SYT/SSX1 & SYT/SSX2 fusion transcripts

323

Medical treatment options in UBC

Bone graft (poor success with high recurrence rates)

Steroid

autologous bone marrow (controversial - may be better than steroids)

JAAOS 2014

324

Why must you follow chordoma patients long term post resection?

1. High recurrence rate

2. Mets occurs late in disease

Occurs in 30-50% to lung, rarely bone

325

Nonoperative mangement of Paget's

When is it indicated

Bisphosphonates

Calcitonin

Indicated in sympomatic cases

asymptomatic you just treat supportively

326

 

What tumor shows predilection for the distribution shown in this figure?

 

Chondroblastoma

327

 

What extra-articular tumor has pathology similar to PVNS?

 

Giant cell tumor of tendon

328

What are the basic types of soft tissue sarcoma (think histo)

Synovial (sarcoma)

Lipo(sarcoma)

Rhabdomyo(sarcoma)

Fibro(sarcoma)

329

GCT histology?

Mononuclear cells with Uniformly distributed multinucleated giant cells