Tumour Immunology Flashcards Preview

Year 2 > Tumour Immunology > Flashcards

Flashcards in Tumour Immunology Deck (16)
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1
Q

Name two types of cancers we can inherit

A
  1. Transformation of germline cells (INHERITABLE CANCERS)

2. Transformation of somatic cells (NON-INHERITABLE CANCERS)

2
Q

Which are more common, non-inheritable or inheritable cancers

A

Non-inheritable - 90% of all cancers

3
Q

What cancer do UV contribute to

A

Skin

4
Q

What cancer do chemicals contribute to

A

Lung

5
Q

What cancer to HPV cause

A

Cervical

6
Q

What cancer do helicobacter cause

A

stomach cancer

7
Q

Why do cancers continue to grow

A
  1. Evade apoptosis
  2. Ignore anti-proliferative signals
  3. Limitless replication potential
  4. Sustained angiogenesis
  5. Escape immune surveillance
8
Q

What is the ultimate goal of tumour immunology

A

Induce clinical effective anti-tumour immune responses that would discriminate between tumour cells and normal cells in cancer patients

9
Q

What is cancer immunosurveillance

A

Immune system can recognise and destroy newly transformed neoplastic cells

10
Q

What is cancer immunoediting

A

Tumours tend to be genetically unstable and so the system can kill and induce changes in the tumour resulting in tumour scape and recurrence

11
Q

What are TSAs

A

Peptides on the surface of tumour cells

12
Q

Where are TSAs (Tumour-specific antigens) found

A

Only on tumours

13
Q

How do Tumour Specific Antigens form

A

Point mutations or gene rearrangement

14
Q

Where are TSAs derived from

A

Viral antigens

15
Q

Where are Tumour Associated Antigens found

A

On both normal and tumour cells

16
Q

What is the difference between TAAs found on tumour cells compared to those found on normal cells

A

Over expression on tumour cells

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