Tumour pathology 3 % + Flashcards Preview

ME2308 Principles of Disease > Tumour pathology 3 % + > Flashcards

Flashcards in Tumour pathology 3 % + Deck (10):
1

what are the local Effects Of
Benign Tumours?►

–Pressure

–Obstruction

2

what are the Local Effects Of
Malignant Tumours? ►

Pressure

•Obstruction

•Tissue destruction–Ulceration/infection

•Bleeding–Anaemia or Haemorrhage

•Pain –Pressure on nerves  or Perineural infiltration or Bone pain from pathological fractures

•Effects of treatment

 

3

what are the Systemic Effects Of Malignant Tumours?

•Weight loss-cancer (cachexia)

•Secretion of hormones

–“Normal”

–“Abnormal”/inappropriate

•Paraneoplastic syndromes

•Effects of treatment

4

Define normal and abnormal hormone secretion in sytematic effects of cancer?

  • “Normal” - produced by tumours of endocrine organ,but abnormal control of hormone production/secretion
  • “Abnormal”/inappropriate - produced by tumour from an organ that does not normally produce hormone

5

what is the significance of early detection in cancer?

Reduce/prevent morbidity/mortality

•Detection at pre-invasive stage

–Identification of dysplasia/intraepithelial neoplasia

6

what is Dysplasia?

Pre-malignant change

Earliest change in the process of malignancy that can be visualised.

•Identified in epithelium

No invasion

•But can progress to cancer

 

 

7

what are the features of Dysplasia?

•Disorganisation of cells

–Increased nuclear size

–Increased mitotic activity

–Abnormal mitoses

•Grading of dysplasia

–High grade

–Low grade

No invasion

8

Examples of inappropriate secretion of hormones for lung cancer

  • ACTH
  • ADH

9

Paraneoplastic syndrome

  •  a syndrome (a set of signs and symptoms) that is the consequence of cancer in the body, but unlike mass effect, is not due to the local presence of cancer cells.
  • In contrast, these phenomena are mediated by humoral factors (such as hormones or cytokines) excreted by tumor cells or by an immune response against the tumor.

10

Intraepithelial neoplasia►

Intraepithelial neoplasia (IEN) is the development of a benign neoplasia or high-grade dysplasia in an epithelium.

Neoplasia: the presence or formation of new, abnormal growth of tissue.