Unit 3.3

Question 1

Complement

Answer 1

allows recognition & destruction of pathogens based on PAMPs; innately complements the humoral branch of the immune system plasma factors made by the liver

Question 2

Complement Actions

Answer 2

Opsonization to enhance phagocytosis, chemotaxis/inflammation, cell membrane lysis, removal of antibody complexes (type 2 hypersentivity)

Question 3

Zymogens

Answer 3

inactive proteases that circulate as complement factors

Question 4

Gram Negative

Answer 4

bacteria, viruses, RBCs, parasites, & nucleated cells that complement works on

Question 5

Types of Complement Pathways

Answer 5

Classical, Lectin, Alternative

Question 6

Classical

Answer 6

third to act; antibody mediated, requires 2 IgG or 1 IgM molecule

Question 7

Lectin

Answer 7

second to act; antibody independent, mannose-binding lection & ficolins bind to carbohydrates, MBL associated serine proteases (MASPs)

Question 8

Alternative

Answer 8

first to act; spontaneous activation

Question 9

Anaphylotoxins

Answer 9

cause mast cell degranulation, C5a most potent

Question 10

Complement Receptors

Answer 10

CR1, CR2, CR3, CR4, C3aR, C5aR

Question 11

CR1

Answer 11

erythrocytes; immune complexes

Question 12

CR2

Answer 12

B cells

Question 13

CR3

Answer 13

enhances opsonization of immune complexes

Question 14

CR4

Answer 14

phagocytosis

Question 15

C3aR

Answer 15

induces degranulation

Question 16

C5aR

Answer 16

induces degranulation