Uterus path II Flashcards
What are the cancers that arise in the epithelium of the endometrium
hyperplasia/EIN
adenocarcinoma
what are the types of adenocarcinomas of endometrium
type I- glandular
non endometroid which is type II- surface
types of type II-surface endometrial adenocarcinomas
papillary serous carcinoma
MMMT carcinosarcoma
majority of endometrial CA are what type
endometroid adenocarcinoma- type I
endometroid adenocarcinomas present when
45-55 y.o
endometroid adenocarcinoma is assoc with what
exogenous E endogenous E E from peripheral conversion of androgen infertility DM and HTN
what mutations can occur with endometroid adenocarcinom
PTEN mutations
microsatellite instability in KRAS gene assoc with HNPC lynch syndrome
presentation of endometroid adenocarcinoma
abrnomal bleeding, spotting or staining
how does endometroid adenocarcinoma spread
direct extension, late spread to nodes and distance mets
risk factors for endometrial cancer
increasing age E therapy tamoxifen therapy early menarch late menopause >55 obestiy DM lynch syndrome
what do the grades of endometroid adenocarcinoma relate to
percent that is solid
with a Bx of the endometrium is suspect adenocarcinoma what should you stain for
PTEN
if adenocarcinoma in endometrium has p53 mutation what is it
serious carcinoma, non-endometroid (type II)
how should you follow a non-endometroid adenocarcinoma (type II)
high grade, 2/3 with aggressive course
early spread in lymph and into fallopian tubes to peritoneal cavity
follow closely!!
has papillary architecture
What are MMMT tumors
malignant mixed mullerian tumors, carcinosarcomas
bulky polypoid mass
epithelial and mesenchymal components
when does non endometroid adenocarcin type II usually arise
65-75 y.o
clinical setting of those affected with non endometroid adenocarcinoma
atrophy, thin physique
common in african americans
morpholocy of the non endometroid adenocarcinoma
serous, clear cell with mixed mullerian features
non endometroid adenocarcinoma is a precursor ro what
endoetiral intraepithelial carcinoma
which lynch syndrome genotype is most closely relate dot endometrial cancer
MLH1
What is grade 3 adenocarcinoma
poorly differentiated >50% solid growth
what is stage 1 adenocarcinoma
carcinoma confined to corpus uteri itself
what is stage 3 adenocarcinoma
outside uterus but not outside true pelvis
what is satge 4 adenocarcinom
outside true pelvis, may involve mucosa of bladder or rectum
