Ovaries path I Flashcards Preview

Year2 Repro exam I > Ovaries path I > Flashcards

Flashcards in Ovaries path I Deck (54):
1

what are follicular cysts

common
form if no LH surge and cyst does't rupture to release its egg, continues to grow and forms cyst
usually reabsorb after 2-3 menstrual cycles

2

what causes a corpus luteum cyst

if opening from released egg seals off the subsequent corpus luteum can grow into a cyst

3

what can occur with corpus luteum cyst

may hemorrhage or udnergo torsion

4

what is an endometrioma

chocoloate cysts from repeated menstural cycles

5

youn women with sudden unilateral low abdominal pain

torision of ovary

6

what do you have to rule out if suspect torsion of ovary

ectopic pregnancy

7

what is Tx for torsion of ovary

surgery to unwind ot remove

8

what is the #1 cause of torsion of ovary

teratoma

9

risk factors for ovarian torsion

increased length of ovarian ligament/large ovary

10

What are components of polycystic ovary disease

oligomenorrhea
hyperandrogenism: hisutisms, inc muscle mass, large clitoris, baldness, acne
polycystic ovaries
obesity, acanthosis nigricans, DM, insulin R, premature ASD, high cholesterol

11

what disease do you rule out for PCOD

thyroid problems, pituitary problems

12

what is stromal hyperthecosis

overlaps with PCOD
both ovaries enlarged with hormonally active ovarian stroma
most common in postmenopausal women
virilizaiton may be striking

13

how does ranking of hirsutism work

scale 0-4, 4 being the most hair

14

if suspect PCOD what are labs to order

Testosterone levels at 8 am
24 hr urine cortisol levels
DXM suppression test

15

definition of infertility

failure to conceive after 1 year of sex
> 6mo if >35 y.o

16

what is fecundity

likeliehood of pregnancy over time
25-50% <3 mo
85% in 1 yr

17

what can cause pale infertility

endocrine, poor sperm

18

23 y.o female complaining of infertility
labs to order

day 21 P
3 ng/mL= recent ovulation
endometrial Bx

19

if 23 y.o infertile patient is anovulatory what could be causes of infertility

PCOS: increased androgen, ovarian cysts
PRL levels, TSH, FSH

20

if 23 y.o infertile patient does have ovulation what could be cause of infertility and what lab do you do.

hysterosalpingogram to see if blocked or patent
blockage could be PID or mechanical
if patent could be endometriosis, uterine masses, lesion... etc

21

what lab level will determine if 40 y.o F has ovarian failure

if day 3 FHS levels are increased

22

majoirty of malignant ovarian tumors are what type

serous tumors, surface epithelial
(cystadenomas, borderline tumors, adenocarcinomas type I and III)

23

what are the types of surface epithelial tumors of ovaries

serous
mucinous
endometroid

24

what are the sex cord-stromal tumors of ovaries

granulosa, fibrothecomas and sertoli-leydig tumors

25

what are the germ cell tumors of ovaries

teratoma, dysgerminoma, endodermal, sinus (yolk sac)

26

second most common malignant ovarian tumors

endometroid tumors- adenocarcinoma type I and II

27

when are ovarian cancers discovered

late presentaiton because often asymptomatic

28

what are the hereditary assocaitions with ovarian cancer

BRCA 1 and 2
lynch II syndrome MSH2

29

prognosis of ovarian cancer really depends on what

stage

30

which ovarian cancers are mroe commonly b/l

serous and endometrial

31

What is used to follow already Dx ovarian cancer

CA-125

32

what decreases risk of ovarian cancer

tubal ligation, BCP

33

wehre do most serous ovarian CA arise

distal fallopian tube

34

what is a serous cystadenoma

benign common
lined by single layer epithlium

35

what is a serous borderline carcinoma

more cytologic atypia but NO invasion
usually spread to peritoneum
good survival

36

what is a serous adenocarcinoma

INVASIVE
type I is low grade- slow progression
type II is aggressive high grade and presents late (if mets <10 % survival

37

histo of serous adenocarcinoma

single cells that line cyst wall and ciliated
fallopian tube also ciliated

38

what classifies "borderline"

in between category
no evidence of invasion

39

Tx for borderline carcinomas

remove

40

what is exophytic serous carcinoma

surface ovary covered by neoplas

41

what is cystic serous carcinoma

surface of ovary is smooth because neoplasm inside

42

serous adenocarcinoma can have what unique histo cahracteristic that is pathoneumonic

psammomma bodies

43

most mucinous tumors are benign or malignant

benign

44

what utation is assoc with mucinous tumors or ovaries

KRAS

45

what is pseudomyxoma peritonei

mucinous ascites with metastatic tumor on peritoneal surfaces

46

what are endometroid tumors type II markers

p53, CDH1, MI

47

what are the endometroid tumors type I markers

PTEN and KRAS and beta cetenin

48

mutation assoc with clear cell carcinoma of ovaries

PTEN mutations or loss of heterozygosity PIK3CA mutation

49

high grade serious carcinomas and high grade endometroid carcinomas are assoc with what mutations

p53
BRCA1

50

cytological markers for high grade serous carcinoma of ovary

p53
WT1
Pax8
ER+

51

cytologic markers for low grade serous carcinoma of ovary

WT1 Pax8

52

cytologic markers for endometroid carcinomas of ovary

ER +
PAX8+
WT negative!

53

cytologic markers for clear cell carcinoma of ovary

HNF beta+
negative WT!
ER negative!

54

cytologic markers for mucinous carcinomas of ovary

CK20+
ER negative!
WT negative!