Ovaries path II Flashcards Preview

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Flashcards in Ovaries path II Deck (26):
1

Sx for surface epithelial tumors

lower abdominal pain, GI complaints, ascites GU complaints, pelvic pressure, progressive weakness, weight loss, cachexia end stage

2

what is peritoneal carcinomatosis

diffuse seeding of peritoneum

3

Tx for surface epithelial tumors

surgery

4

where do surface epithelial tumors mets to

mesothelial surface (ovarian serous carcinoma to malignant ascites
lymph nodes
liver, lungs, bone, CNS

5

which serum to ascites albumin gradient is characteristic of peritoneal carcinomatosis

<1.1 g/dL
low albumin gradient

6

most common cancer to cause ascites

ovary- serous type

7

what are the hormonaly active tumors that secrete E in postmenopausal women

granulosa theca cell tumors

8

what biomarker is used to Dx granulosa theca cell tumor

inhibin
FoxL2 mutation

9

Call Exner bodies on histo

granulosa theca cell tumor

10

what are fibromas

solid white hard fibrous tumor
usually unilateral

11

what syndrome are fibromas assoc with

meig syndrome: ascites pleural effusion and ovarian fibroma that resolves with resection of fibroma

12

which tumors can produce androgens

sertoli leydig cell tumors
leads to virilization, hirsutism, male escuthecon, deepen voice, increase clitoris size, defeminization

13

germ cell tumors are dangerous in what age group

children- malignant
adults- benign

14

what classifies a benign cystic teratoma or dermoid "mature teratoma"

2 or 3 germ cell lines
rokitanski nodule on cysts wall

15

what type of cancer can develop(rare) from benign teratoma

SCC

16

describe immature malignant teratoma

girls and adlescents
immature tissues
rapid growth and spread
prognosis depends on grade and stage

17

what are monodermal teratomas

single tissue predominates
carcinoids or struma ovarii(thryoid)
functional and can cause hyperthyroidism and carcinoid syndrome

18

What germ cell tumors are always malignant

dysgerminomas

19

Tx for dysgerminoma

radiotherapy
if unilateral and confined can do salpingo-oophorectomy

20

what are endodermal sinus tumors
"yolk sac"

aggressive
in children and young adults
need chemo

21

characteristics of yolk sac tumors

schiller duval bodies
produce alpha fetoprotein and alpha 1 antitrypsin

22

what is a choriocarcinoma

usually in another germ cell tumor
mixed pattern- aggressive

23

what do choriocarcinomas produce

beta HCG at high levels!
helpful in Dx

24

metastatic carcinomas found in ovary usually arise from where

mullerian organs: uterus fallopian tube, opp ovary or peritoneum

25

what extramullerian organs can mets to ovaries

breast and GI

26

what is krukenberg tumor

b/l mets of mucin-producing, signet ring cancer cells, (GI origin!!)