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Flashcards in V - Diseases of the Immune System Deck (105)
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61

Main cellular target of HIV.

CD4+ helper T cells(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.158

62

P.carinii pneumonia occurs in AIDS patients with CD4+ T cell count of ______.

Less than 200 cells/uL(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.163

63

Most common secondary infection of the CNS in patients with AIDS.

Toxoplasmosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.163

64

Most common neoplasm in AIDS patients, caused by HHV8. Characterized by cutaneous lesions with or without internal involvement.

Kaposi sarcoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.164

65

A disorder of protein misfolding, causing extracellular deposition of pink or red colored deposits stained with Congo red, with apple-green birefringence in polarized light.

Amyloidosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.166

66

Cells of immune system

T- and B-lymphocytes, dendritic cells, macrophages, natural killer cells, innate lymphoid cells. (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 190

67

Tissues of the immune system

Bone marrow, thymus, lymph nodes, spleen, mucosal and cutaneous lymphoid tissue. (TOPNOTCH) Robbin Basic Pathology, 9th ed., p. 193

68

The most important antigen-presenting cells for initiating T-cell responses against protein antigens

Dendritic cells(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 191

69

A 48 y/o male patient underwent kidney transplant suddenly developed bloody urine few hours after the procedure. Nephrectomy was done and revealed a cyanotic, mottled, and flaccid kidney and necrotic kidney cortex. There is neutrophilic accumulation in the arterioles, glomeruli, and peritubular capillaries. Glomeruli undergo thrombotic occlusion of capillaries and fibrinoid necrosis in arterial walls. The most likely diagnosis is:

Hyperacute rejection (TOPNOTCH) Robbin Basic Pathology, 9th ed., p. 233

70

A 45 y/o female presented with signs of kidney failure 2 months after her renal transplant. Immunohistochemical staining reveals both CD4+ and CD8+ lymphocytes. Morphologic findings showed an extensive interstitial inflammation with infiltration of tubules and focal tubular injury. This is a case of:

Acute cellular (T-cell mediated) rejection (TOPNOTCH) Robbin Basic Pathology, 9th ed., p. 234

71

Preformed antidonor antibodies present in the circulation of the recipient is implicated in what type of rejection pattern?

Hyperacute rejection (TOPNOTCH) Robbin Basic Pathology, 9th ed., p. 233

72

A 30 y/o male developed oliguria and subsequent renal failure 3 weeks after an uneventful kidney transplant. Renal findings showed inflammation of glomeruli and peritubular capillaries, deposition of complement breakdown and focal small vessel thrombosis. This is a case of:

Acute antibody-mediated rejection (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 234

73

A 24 y/o female diagnosed with renal failure underwent renal transplant. Four years later, increasing levels of creatinine was noted, and biopsy showed an interstitial fibrosis and tubular atrophy, glomerulopathy with duplication of basement membrane, and multilayering of peritubular capillary basement membranes. Interstitial mononuclear cell infiltrates, NK cells and plasma cells were also noted. This is a case of:

Chronic rejection(TOPNOTCH)Robbins Basic Pathology, 9th ed., p.234

74

The result of hypoplasia or lack of thymus in DiGeorge Syndrome

Variable loss of T-cell mediated immunity (TOPNOTCH) Robbins Basic Pathology, 9th ed., p.241

75

The hallmark of AIDS

Profound immune deficiency, primarily cell-mediated immunity (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 245

76

A 32-year old female, presents to the clinic with symptoms of fatigue, joint pains, and malar rash. CBC revealed anemia and low platelet count. The most likely diagnosis is:

Systemic Lupus Erythematosus (TOPNOTCH)

77

The hallmark of SLE

Production of autoantibodies (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 218

78

The fundamental defect in SLE

Failure of mechanisms that maintain self-tolerance (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 219

79

Most common manifestation of SLE

Hematologic manifestation (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 218

80

Most common hematologic finding in SLE

Anemia(TOPNOTCH)

81

Most common and most severe form of lupus nephritis

Diffuse lupus nephritis/Class IV(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 224

82

The most common causes of death in SLE

Renal failure and intercurrent infections (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 225

83

Cytokine most firmly implicated in the pathogenesis of Rheumatoid arthritis

TNF (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1210

84

Major cytokine produced by TH1, stimulates macrophage activation and IgG antibody production. Plays a role in autoimmune and other chronic inflammatory diseases.

IFN-gamma(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 198

85

The dominant immune reactions of these subset of helper cells are the stimulation of IgE production and activation of mast cells and eosinophils.

TH2(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 198

86

These are the mediators of adaptive immunity and the only cells that produce specific and diverse receptors for antigens

Lymphocytes(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 199

87

Immunity mediated by antibodies and is effective against extracellular microbes in the circulation and mucosal lumens.

Humoral immunity(TOPNOTCH)Robbins Basic Pathology, 9th ed p. 200

88

Type of immunity design to combat phagocytosed microbes and microbes in the cytoplasm of infected cells.

Cell-mediated immunity(TOPNOTCH)Robbins Basic Pathology, 9th ed p. 200

89

These are cells the help B cells to make antibodies, activate macrophages to destroy ingested microbes, stimulate recruitment of leukocytesand regulate all immune responses to protein antigens.

CD4+ helper T cells(TOPNOTCH)Robbins Basic Pathology, 9th Ed p.200

90

These are cells that express antigens in the cytoplasm that are seen as foreign, such as virus-infected and tumor cells.

CD8+ cytotoxic T lymphocytes(TOPNOTCH)Robbins Basic Pathology, 9th Ed p.200