Vaccine Delivery (Haddadi Lecture)

Question 1

Who invented the Smallpox Vaccine?

Answer 1

Edward Jenner (1796)

Question 2

Provide examples of Therapeutic Vaccines (e.g. Individual already infected but we immunize to stimulate better response).

Answer 2

Cancer
Viral / Bacterial Dx
Alzheimer’s Disease

Question 3

What is a “Tolerogenic Vaccine”?

Answer 3

Vaccine developed against self-antigens (e.g. Organ Transplantation).

Question 4

What are the Primary Lymphoid Organs?

Answer 4

Bone Marrow, Thymus (maturity of B Cells & T Cells respectively).

Question 5

What are the Secondary Lymphoid Organs?

Answer 5

Lymph Nodes

Spleen

Mucosal Lymphoid Tissues (ie. Lung, Gut)

Question 6

T or F: Antigen presentation in isolation produces a productive immune response.

Answer 6

False!!! Require addition of an Adjuvant to stimulate Immune Response.

Question 7

How do Dendritic Cells distinguish between ‘self’ & ‘non-self’?

Answer 7

PAMPs (Pathogen-Associated Molecular Patterns)

Question 8

What are the benefits of adding Adjuvants to vaccines?

Answer 8

-Enhance immunogenicity of weak antigens

-Reduce amount of antigen needed to infer immunity

-Improve efficacy in weakened / reduced immune system patients

Question 9

MF59 & PLG are examples of what?

Answer 9

Vaccine Delivery Systems

Question 10

CpG, MPL, & SMIPs are examples of what?

Answer 10

Immune Potentiators