Vascular Infections Flashcards
obligate intracellular, gram-negative coccobacilli; tick-borne; closely related to Anaplasma and Ehrlichia; infects vascular endothelial cells; causes Rocky Mountain Spotted Fever; thought to be “black measles”; diffuse across country/world
Rickettsia rickettsii
Where was Rocky Mountain Spotted Fever discovered and the organism isolated?
Montana
Why is rickettsia rickettsii an obligate intracellular bacteria?
Divide in the cytoplasm
Utilize host carbon sources and ATP
Utilizes host actin for motility
Rickettsia rickettsii can be cultured without host cells (True or False)
False
Target tissue for R. rickettsii
Vascular endothelial cells
Endothelial damage due to R. rickettsii
Damages membrane and platelets bind (DIC)
Leakage of blood out of vessels (shock)
Symptoms of R. rickettsii
Chills, fever, headache
Rash (90%): red, maculopapular, petechial (on extremities and then trunk)
Sudden onset vasculitis
Without treatment, the fatality of R. rickettsii is…
25%
First line treatment for R. rickettsii; easily penetrates cells; targets mRNA and ribosome (no translation); doesn’t cause teeth staining
Doxycycline
Treatment within first ____ days of symptoms with doxycycline is highly effective for R. rickettsii
5
robovirus (rodent-borne); enveloped RNA virus with segmented genome; infects capillary endothelial cells; low seroprevalence; trasmitted via aerosols contaminated with rodent feces/urine
Hanta virus
Symptoms of Hanta virus
Fever Chills Myalgia Cough Dyspnea Cardiovascular collapse
Examples of Human Herpes viruses
HSV1/2 Varicella Zoster EBV CMV HHV 6/7/8
Human herpesviruses are enveloped, ss RNA viruses (True or False)
False; enveloped ds DNA viruses
Herpesvirus that infects myeloid, smooth muscle and endothelial cells; negative monospot
CMV
