Viral Families Flashcards Preview

MIS > Viral Families > Flashcards

Flashcards in Viral Families Deck (27):
1

ADENOVIRIDAE

Icosahedral (252)
NO envelope
linear dsDNA
e.g. Mastadenovirus

2

HERPESVIRIDAE

Icosahedral (162)
YES enveloped
linear dsDNA
e.g. Herpesvirus
Varicella-zoster
Cytomegalovirus
Epstein-Barr virus

3

POXVIRIDAE

Complex Structure
Yes enveloped (ether resistant)
linear dsDNA
e.g. Orthopoxvirus

4

PAPILLOMAVIRIDAE

Icosahedral (72)
No envelope
closed circular dsDNA
e.g. Papillomavirus

5

POLYOMAVIRIDAE

Icosahedral (72)
No envelope
closed circular dsDNA
e.g. JC virus

6

PARVOVIRIDAE

Icosahedral (32)
No envelope
linear ssDNA
e.g. Parvoviruses

7

HEPADNAVIRIDAE

Icosahedral (42)
Yes enveloped
circular dsDNA
e.g. Hepatitis B virus

8

PICORNAVIRIDAE

Icosahedral (32)
No envelope
No Transcriptase
(+) ssRNA
e.g. Enteravirus (enteric)
Rhinovirus (respiratory)

9

CALICIVIRIDAE

Icosahedral (32)
No envelope
No Transcriptase
(+) ssRNA
e.g. Calicivirus (Norwalk virus)

10

ASTROVIRUS

Icosahedral (32)
No envelope
No Transcriptase
(+) ssRNA
e.g. Astrovirus

11

CORONAVIRIDAE

Helical, enveloped, petal-shaped spikes
No Transcriptase
(+) ssRNA
e.g. Coronavirus

12

TOGAVIRIDAE

Icosahedral
Enveloped
(+) ssRNA
No transcriptase
e.g. Rubivirus (rubella)

13

FLAVIRIDAE

Icosahedral
Enveloped
(+) ssRNA
No transcriptase
e.g. Flavivirus

14

BUNYAVIRIDAE

Helical
Enveloped

15

Immunogen

Any compound that is capable of inducing an immune response

16

Hapten

A compound that can interact with an Ab but is not capable of inducing an immune response on its own

17

Antigen

Any compound that can interact with antibody or TCR

18

Epitope

Portion of an antigen that interacts with an Ab or TCR

19

Conformational epitope

exist only on the surface of native
folded protein

the majority of B cell epitopes

20

Linear epitope

continuous amino acid sequence
in polypeptide

the majority of T cell epitopes

21

Cross-reactivity

Recognition by Ab (or TCR) of an epitope other than the one that induced immune response.

Cross-reactive epitope is usually bound less well, but also may be bound better.

22

Antigenic Drift

a mechanism for variation in viruses that involves the accumulation of mutations within the genes that code for antibody-binding sites.

23

Antigenic Shift

BAD BAD BAD! the process by which two or more different strains of a virus, or strains of two or more different viruses, combine to form a new subtype having a mixture of the surface antigens of the two or more original strains.

24

Molecular mimicry

Cross-reacting epitopes can exist on structurally distinct molecules that share structural homology

Strepococcal pyogens --> Rheumatic fever

25

Affinity

A measure of the strength with which a single epitope interacts with a single Ag-binding site.
[monovalent Ag]

26

Avidity

The stability of interaction for immune complexes that consist of different antibodies (with different affinities) and multiple epitopes.
[multivalent Ag]

27

Type III hypersensitivity reaction

Inefficient Removal of Ab/Ag Complexes Formed by Excessive Ag Can Have Serious Consequences
e.g. serum sickness