WK18D3 Inflammation Flashcards Preview

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Flashcards in WK18D3 Inflammation Deck (16):
1

Briefly after wound, __ occurs. Then, vasodilation due to smooth muscle relaxation mediated by __, __, __. Results in increased flow and transient ___ of fluid.

Vasoconstriction
NO, histamine, PGI2
transudation

2

4 ways of vascular leakage or increased permeability include

endothelial contraction (briefly), then junctional retraction. Also via direct injury or leukocyte-dependent damage.

3

How do endothelial cells attract leukocytes? Which molecules do leukocyte rolling and binding?

Histamine, bradykinin, endotoxin, cytokines (IL-1/TNF-alpha)
Rolling: P-selectin
Binfing: integrins and Ig-like proteins

4

If you see neutrophils in a wound (<24 hr old), it is ___ inflammation. Also involved are ___, ___, and ___. In 48-72 hr period, they are replaced by ___.

acute
macs, eos, basos
monocytes

5

Endothelial junctions and invaginations express self-binding ____. Leukocytes express it and bind to everted ____ so they can begin ___. No ___ is lost in the process.

PECAM (CD31)
invaginations
diapedesis
fluid

6

Chemokine concentration gradients are important for ___. The gradient is maintained via local retention on ___ and ___. The ___ acts as a sink removing chemokines from circulation to maintain gradient.

Chemotaxis
proteoglycans, nearby endothelium
Duffy antigen receptor

7

4 Oxygen dependent killing mechanisms include __. If their production is broken, you have ___. O2-independent mecanisms include

superoxides, myeloperoxidase-dependent killing (bleach), hydroxyl radicals, H2O2
Chronic granulomatous disease
lysozyme, lactoferrin, MBP, defensin, BPI

8

4 end-results of acute inflammation. It may involve this gross substance...

Resolution, scarring, abscess, chronic inflammation

pus

9

Major immune cell types for chronic inflammation include __, __, and ___. Non-immune cell types are ___ and ___.

Monocyte, plasma cell, lymphocytes
Fibroblast and endothelial cell

10

Macrophages are key in chronic inflammation because...

Killing ability
Long-lived
Proliferative
Chemotactic for other cells

11

Chronic granulomatous inflammation can be seen via ___. They are ___ aggregates of ___ macs. Occur when ___ aren't removed, induced by __. Classic examples are...

Circumscribed
Epithelioid
Pathogens
T-cell mediated rxns (Th1)
TUBERCULOSIS, syphilis, sarcoid (in SE US), fungal, foreign bodies.

12

Systemic effects of inflammation

Fever
Cachexia
Leukocytosis
Coagulopathy
Capillary Leakage

13

Inflammatory molecules __, ___, and ___ induce __ from the liver. Important ones include ___, ___, ___.

IL-1, TNF, IL-6
Liver
C-reactive protein, fibrinogen, SAA (serum amyloid protein).

14

NOS isoenzymes have 3 types: Type I (nNos) is constitutive in ___, __-dependent. Type II (iNOS) is ___ by __, __, __,and __. Type III (eNOS) constitutive in ___ and regulates ___ and ___.

neurons, Ca++
inducible, TNF-alpha, IL-1, LPS, IFN-gamma
endothelium
vascular tone, leukocyte recruitment

15

Defensins are antimicrobial molecules released from ___ cells in intestinal ___.

Paneth cells
crypts

16

Autosomal recessive disorder, defective MT polymerization forming giant lysosomes in WBCs.
It results in ____, associated with ___.

Chediak-Higashi syndrome
Recurrent infections
Albinism