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Flashcards in Virology Deck (170):
0

All enveloped virus acquire their envelop from plasma membrane except

Herpes virus - nuclear membrane

1

Enumerate the Naked Viruses

naked CPR and PAPP smear
RNA
Calici
Picorna
Reo

DNA
Parvo
Adeno
Papilloma
Polyoma

2

All viruses are haploid except

Retrovirus

3

Enumerate the segmented genome

B O A R
Bunyavirus
Orthomyxovirus - influenza
Arenaviruses
Reoviruses

4

Enumerate the Negative Strand RNA viruses

Always Bring Polymerase Or Fail Replication
Arena
Bunya
Paramyxo
Orthomyxo
Filo
Rhabdo

5

Causes epidemics

Genomic re assortment
Ex influenza

6

One virus produces a protein that can be used by another virus

Complementation
Ex hepa b and d

7

Two different viruses infect the same cell

Phenotypic mixing

8

Infected cells appear normal, but are producing large numbers of progeny virus

Commensal symbiosis

9

Reduce the expression of APC and inactivate complement

Virokines

10

Attachment of RBCs to surface on infected cells

Hemadsorption

11

The only live attenuated vaccine that may be given to HIV positive patient

MMR

12

Enumerate the live attenuated vaccines

Small pox
Yellow fever
Chicken pox
Sabins polio
MMR

13

Enumerate the Killed vaccine

RIP Always
Rabies
Influenza
Polio Salk
Hepatitis A

14

Enumerate the DNA viruses

HHAPPPPY
Hepadna
Herpes
Adeno
Parvo
Papilloma
Polyoma
Pox

15

All DNA viruses have double stranded DNA except

Parvovirus

16

All DNA viruses havelinear DNA except

Hepadna
Papilloma
Polyoma

17

All DNA viruses have icosahedral except

Poxvirus

18

All DNA viruses replicate in the nucleus except

Poxvirus

19

The only virus with fiber

Adenovirus
Penton fibers

20

Histopathology findings of adenovirus

Cowdry type b intranuclear inclusions

21

Histopathology findings of poliovirus

Cowdry type b intranuclear inclusions

22

Histopathology findings of herpes simplex virus

Cowdry type a intranuclear inclusions

23

Diseases cause by Adenovirus

Brochitis
Conjuctivitis
Coryza
Cystitis hemorrhagic
Gastroenteritis
Pharyngitis
Pneumonia atypical

24

Virus that infects squamous cells and induce formation of cytoplasmic vacuoles called koilocytes

HPV

25

Genes that encode proteins that inactivate tumor suppresor genes

E6 and E7

26

HPV that causes skin and plantar warts

1 to 4

27

HPV that causes genital warts, respiratory tract papillomas

6 and 11

28

MCC of viral STD

HPV 6 11

29

HPV that causes carcinoma of the cervix penis and anus

16 18 31 33

30

Treatment for genital warts

Podophyllin

31

Treatment for skin warts

Liquid nitrogen

32

Treatment for plantar warts

Salicylic acid

33

A drug that acts as an immune disease modifier
Used in actinic keretosis, squamous cell basal carcinoma, condyloma acuminata

Imiquinod

34

Vaccine for HPV consists of

6 11 16 18

35

Virus that causes progressive multifocal leukoencephalopathy PML in patients with AIDS

JC polyoma virus

36

Virus that causes hemorrhagic cystitis and nephropathy in patients with solid organ and bone marrow transplant

BK Polyoma Virus

37

Primary infection, recurrent infection and route of transmission of HSV 1

Stomatitis
Heroes labialis, encephalitis
Secretions and saliva

38

Primary infection, recurrent infection and route of transmission of HSV2

Herpes genitalia, Perinatal infection
Herpes genitalia
Sexual and perinatal

39

Primary infection, recurrent infection and route of transmission of VZV

Varicella
Zoster
Respiratory secretions

40

Primary infection, recurrent infection and route of transmission of EBV

Infectious mononucleosis
None
Respiratory secretions and saliva

41

Primary infection, recurrent infection and route of transmission of CMV

Congenital mononucleosis
Asymptomatic shedding
Intauterine, transfusions, sexual contact, secretions

42

Primary infection, recurrent infection and route of transmission of hHV 8

Uncertain
Kaposis sarcoma
Sexual or organ transplantation

43

Enumerate the Herpes Viruses

Get Herpes on a CHEVrolet
CMV
HSV
EBV
VZV

44

Site of latency of HSV 1

Trigeminal ganglia

45

Site of latency of HSV 2

Lumbosacral ganglia

46

Characteristic rash in Varicella

Vesicular centrifugal rash - dew drop on a rose petal appearance

47

A disease cause by VZV that involves the geniculate ganglion causing facail nerve paralysis

Ramsay hunt syndrome

48

Virus cultured in shell tubes

CMV

49

Positive heterophil test

EBV

50

Negative heterophil test

CMV
Toxoplasma

51

MCC of congenital abnormalities

CMV
MC when the mother was infected in first trimester

52

Diseases presenting as blue berry muffin baby

Congenital CMV, Rubella and Disseminated Neuroblastoma

53

MCC of blindness among HIV patients

CMV retinitis

54

DOC of CMV

Ganciclovir
Largely resistant to Acyclovir

55

Virus that infects mainly the lymphoid cells, primarily B lymphocytes

EBV

56

Atypical lymphocytes in EBV infection

Downy cells

57

Kissing disease

Infectious mononucleosis - EBV

58

A rare complication in Infectious mononucleosis

Splenic rupture

59

Malignancy caused by EBV

Burkitts lymphoma - B cell lymphoma
Unilateral facial swelling, most common in African people

60

MCC Malignancy caused by EBV in Chinese people

Nasopharyngeal carcinoma

61

Disease caused by EBV in AIDS patient

Hairy leukoplakia

62

A malignancy caused by HHV 8

Kaposis sarcoma

63

The only disease that has been eradicated from the face of the Earth

Small pox

64

Largest virus

Small pox

65

Brick shaped poxvirus containing linear dsDNA

Small pox

66

Virus that causes pinkish papular skin lesions with an umbilicated center

Molluscum contangiosum

67

Treatment for Molluscum contangiosum

Cifodovir

68

Enumerate the Hepatitides

Hepatitis
A asymptomatic
B blood borne
C chronic cirrhosis carcinoma carriers
E enteric ecpectant mothers epidemics

69

An enveloped virus with incomplete circular dsDNA

Hepa B

70

The only DNA virus that produces DNA by reverse transcription eith mRNA as the template

Hepa B virus

71

Hepa B is associated with this autoimmune vasculitides

Polyarteritis nodosa

72

Complications of Hepa B

Hepatorenal
Hepatopulmonary
Portal HPN
Hepatic encephalopathy

73

Treatment for Hepa B

Interferon alpha - interferes with viral attachment and replication
Lamivudine

74

First vaccine to prevent a human cancer

Hepa B

75

All RNA viruses have single stranded DNA except

Reo
Rota

76

All RNA viruses replicate in the cytoplasm except

Influenza
Retro

77

Enumerate the RNA viruses

I went to a RETRO TOGA party, where i drank FLAVored CORONA beer and ate HIPPY CALIfornia PICkles
Retro
Toga
Flavi
Corona
Hepa E
Calici
Picorna

78

Enumerate members of picornaviridae

PERCHed on a PIC (peak)
Polio
Echo
Rhino
Coxsackie
Hepa A
Picorna
All are Enterovirus except Rhino-repiratory

79

A virus that replicates in motor neurons in anterior horn of spinal cord causing paralysis

Poliovirus Poliomyelitis

80

Spectrum of disease in Polio

Asymptomatic
Abortive poliomyelitis - most common clinical form, flu like
Non paralytic - aseptic meningitis
Paralytic - flaccid paralysis, permanent motor damage

81

The classification of this virus is based on pathogenicity in mice

Coxsackie virus

82

MCC of viral myocarditis and pericarditis

Coxsackie virus

83

MCC of aseptic meningitis

Coxsackie virus - overall
Other causes: Enterovirus - Polio and Echo

84

Triple H in Coxsackie virus

Herpangina
Hand foot and mouth disease
Hemorrhagic conjunctivitis

85

Echovirus is also known as

Enteric cytopathic human orphan

86

MCC of common colds

Rhinovirus - first
Corona

87

Rhinovirus replicate better at ---, they affect primarily the ---- and -----

33 C
Nose and conjuctiva

88

Rhinovirus is ---- labile

Acid labile - killed by gastric acid when swallowed -- they do not infect the GIT unlike the enteroviruses

89

Hepa -- virus under Picorna virus

Hepa A

90

Also known as Enterovirus 72

Hepa A

91

The most important test in Hepa A

Anti HAV IgM

92

Hepa A is also known as

Enterovirus 72

93

Members of Caliciviridae

Hepa E
Norovirus

94

Hepa E is a member of

Caliciviridae

95

A virus with high mortality in pregnant women

Hepa E

96

MCC of non bacterial diarrhea in adults

Norwalk virus - viral gastroenteritis
Norovirus

97

MCC of childhood diarrhea

Rotavirus
ROTA right out of the anus

98

MCC of respiratory tract infections

Influenza A

99

Major antigens of Influenza virus

Hemagglutinin - binds to the cell surface receptor (neuraminic acid, sialic acid) to initiate infection of the cell - target of neutralizing antibody
Neuraminidase - cleaves NA to release progeny virus from infected cell, also degrades the protective layer of mucus in the respiratory tract to enhace access to the respiratory epithelial cells

100

Antigenic shifts

Influenza A - pandemics

101

Antigenic drifts

Influenza B - epidemic

102

DOC of Influenza virus

Oseltamivir or Zanamivir
For Influenza A only - Amantadine or Rimantadine

103

Diseases caused by Paramyxoviruses

Parainfluenza
RSV
Measles
Mumps

104

A virus with envelope spikes containing HA NA and fusion protein

Mumps
Parainfluenza

105

A virus with envelope spikes containing HA and fusion protein

Measles

106

A virus with envelope spikes containing fusion protein only

RSV

107

Histopathologic findings in Measles

Multinucleated giant cell
Warthin Finkeldey

108

Pthognomonic lesion in Measles characterized as bright red lesions with a white central dot on buccal mucosa near the opening of the Stensens duct

Kopliks spot

109

Complications of Measles

Subacute sclerosing pancencephalitis or Damson disease
Encephalitis
Pneumonia

110

Cardinal manifestations of Measles

Cough
Coryza
Conjunctivitis
Kopliks spot

111

Vitamin --- reduces severity if meales

Vitamin A

112

Diseases caused by Mumps virus

Parotitis
Orchitis
Meningitis aseptic

113

Virus forming multinucleated giant cells

Respiratory syncitial virus

114

Natural hosts of RSV

Humans

115

Most important cause of pneumonia and bronchiolitis in infants

RSV

116

Treatment for Respiratory syncitial virus

Ribavirin
Also use in Hepa C

117

Steeple sign in CXR

Laryngotracheobrinchitis (croup)
Subglottic stenosis

118

Characterized by inspiratory stridor cough and hoarseness

Laryngotracheobrinchitis (croup)

119

Treatment of Laryngotracheobrinchitis (croup)

Racemic epinephrine

120

Bullet shaped virus

Rabies
Rhabdovirus

121

Histopath result in Rabies

Negri bodies

122

Reservoir of Corona virus

Horseshoe bat

123

Intermediate host of Corona virus

Civet cat

124

Corona virus binds to ---- resulting to SARS

ACE 2 receptor

125

CXR result in SARS

Non cavitary ground glass infiltrates

126

Dengue fever is also called

Break bone fever

127

Pleural effusion in Dengue: right or left

Right sided

128

Hepa C is a

Flavivirus

129

It is the most prevalent blood borne pathogen

Hepa c

130

Autoimmune reactions in Hepa C

Thyroiditis
MPGN
Porphyria cutanea tarda
DM

131

Treatment for acute Hepatitis C

Interferon

132

Treatment for chronic Hepatitis C

Peg interferon
Ribavirin

133

Rubella virus is a member of

Togaviridar

134

Causes German measles

Rubella virus

135

Associated abnormalities in Congenital Rubella syndrome

Bulag Cataract
Bingi Sensorineural deafness
Bobo Mental retardation
Butas ang Puso PDA - machinery like murmur
Blue berry muffin baby

136

In Human Immunodeficiency Virus, it is the protein that codes for major capsid protein

P24

137

In Human Immunodeficiency Virus, it is the protein that codes for nucleoprotein

P17

138

In Human Immunodeficiency Virus, it is the protein use for attachment to CD4 protein with antigenicity that changes rapidly

G120
V3 loop - most immunogenic region

139

In Human Immunodeficiency Virus, it is the protein that mediates the fusion of viral envelope with the cell membrane

G41

140

In Human Immunodeficiency Virus, it is the protein that codes for the activation of transcription of viral genes

Tat

141

In Human Immunodeficiency Virus, it is the protein that codes for the transport of late mRNAs to cytoplasm

Rev

142

In Human Immunodeficiency Virus, it is the protein that decreases CD4 and MHC class I proteins

Nef

143

In Human Immunodeficiency Virus, it is the protein that enhances hypermutation

Vif

144

In Human Immunodeficiency Virus, it is the protein that transport nondividing cells

Vpr

145

In Human Immunodeficiency Virus, it is the protein that enhances virion release

Vpu

146

Original source of Human Immunodeficiency Virus

Chimpanzees

147

Principal sources of Human Immunodeficiency Virus in semen

T lymphocyte
Macrophages

148

Definitive diagnosis of Human Immunodeficiency Virus

Western blot analysis

149

Phases in Human Immunodeficiency Virus

Phase
0 infection
1 window period - rapid viral replication but test is negative
2 seroconversion - peak viral load, test is positive, mild flu like illnessm 1-2weeks
3 latent - asymptomatic, cd4 goes down lasts 1-15yrs
4 early symptomatic - cd4-500 to 200, lasts 5yrs, mild derma mucocutaneous and hema illnesses
5 AIDS - cd4 less than 200 lasts 2yrs

150

AIDS defining illnesses with CD4 less than 500

TSEcK
Disseminated Tuberculosis
HSV esophagitis
Esophageal candidiasis
Kaposis sarcoma

151

AIDS defining illnesses with CD4 less than 200

PiTong DIet COC ME
PCP pneumonia
Toxoplasmosis cerebral
Diarrhea chronic
Coccidioidomycosis
Meningoencephalitis

152

AIDS defining illnesses with CD4 less than 50

HiRaP na!
Histoplasmosis
Retinitis CMV
Pulmonary invasive disease

153

AIDS defining illnesses - Prevalence

PCP
Esophageal candidiasis
Wasting
Kaposis sarcoma
Disseminated MAC

154

Treatment for HIV

Highly active antiretroviral therapy HAART
Two nucleoside inhibitors - Lamivudine, Zidovudine
Protease inhibitor - Indinavir

LIZ Uy!

155

Histopathology findings of human T cell lymphotropic virus

Malignant T cells with flower shaped nucleus

156

Retrovirus causing adult t cell leukemia

HTLV

157

Retrovirus causing myelopathy

HTLV

158

MCC of epidemic encephalitis

Japanese B virus
Encephalitis

159

Japanese B virus is trasmitted by

Culex mosquitoes

160

CT scan finding of Japanese B virus

Thalamic infarct

161

CT scan finding of HSV

Temporal infarct

162

Histopathology findings of HPV

Koilocytes

163

Histopathology findings of VZV

Multinucleated giant cells with intranuclear inclusions

164

Histopathology findings of CMV

Giant cells with owls eye appearance

165

Histopathology findings of smallpox

Guarnieri bodies

166

Histopathology findings of molluscum contagiosum

Henderson peterson bodies

167

Histopathology findings of poliovirus

Cowdry type B intranuclear inclusions

168

Viruses with intranuclear inclusions

Polio B
Adeno B
HSV A
VZV MGC
CMV GC with Owls eye

169

Viruses with cytoplasmic inclusions

HPV koilocytes
Smallpox G bodies
Molluscum H and P bodies