Virology Flashcards Preview

Micro > Virology > Flashcards

Flashcards in Virology Deck (111):
1

Live attenuated vaccines

Yellow fever
Chicken pox
Sabin polio
MMR

2

Killed vaccines

Rabies
Influenza
Polio salk
Hepa A

3

Recombinant vaccine

Hepa b
HPV

4

All DNA virus double stranded except

Parvovirus

5

All DNA are icosahedral and replicate in nucleus except

Pox virus

6

Naked DNA viruses

Parvovirus
Adenovirus
HPV

7

Slapped cheek dse

Erythema infectiosum (5th dse)
Parvovirus b19

8

Causes aplastic crises in pt with sickle cell anemia, thalassemia, spherocytosis

Parvovirus B19

9

Chronic B19 infection causes

Pancytopenia

10

Only virus with fiber - penton fiber

Adenovirus

11

MCC of viral conjunctivitis

Adenovirus

12

Cowdry type b nuclear inclusions

Adenovirus
Poliovirus

13

Cytopathic effect of HPV

Koilocytes

14

MC viral STD

Genital warts condyloma accuminata due to HPV 6,11

15

Causes carcinoma of cervix, penis, anus, vulva

HPV 16, 18, 31, 33

16

Ttt for condyloma accuminata

Podophyllin
Imiquimod

17

Causes progressive multifocal leukoencephopathy

JC Polyoma virus

18

Enveloped DNA viruses

Herpes viruses
HHV 8

19

Herpesvirus

CMV
HSV
EBV
VZV

20

Latent site of HSV 1

Trigeminal ganglia

21

Latent site of HSV 2

Lumbosacral ganglia

22

Multinucleated cells on Tzanck smear

HSV

23

Cowdry type A

HSV

24

Temporal lobe encephalitis

HSV 1

25

DOC of HSV

Acyclovir

26

HSV 2 spectrum of dse

Genital herpes
Neonatal herpes
Aseptic meningitis

27

Latent site of VZV

Dorsal root ganglia

28

Multinucleated giant cells with intranuclear inclusions

VZV

29

Facial nerve paralysis due to involvement of geniculate ganglion; VZV

Ramsay hunt syndrome

30

Giant cells with owl's eye inclusions

CMV

31

Impair assembly of MHC class 1 viral peptide complex

CMV

32

MCC of congenital abnormalities

CMV

33

Heterophil neg mononucleosis

CMV

34

MCC of blindness in AIDS

CMV retinitis
CD4

35

DOC for CMV

Gancyclovir

36

Causes blueberry muffin lesion

CMV
Rubella
Disseminated neuroblastoma

37

Malignancy of vascular endothelial cells

Kaposi sarcoma

38

Largest viruses

Small pox

39

Guarneri bodies
Intracytoplasmic eosinophilic inclusions

Small pox

40

Henderson peterson bodies

Molluscum contagiosum

41

Ttt for molluscum contagiosum

Cifodovir

42

Assoc with autoimmune vasculitides
Polyarteritis nodosa

Hepa viruses

43

Ttt for hepatitis

Interferon alpha
Lamivudine

44

All RNA viruses are single stranded except

Rotavirus (Reovirus)

45

Picornaviridae
PERCH

Polio
Echo
Rhino
Coxsackie
Hep A

46

Affects motor neurons in ant horn of SC causing flaccid paralysis

Poliovirus

47

Most common clinical form of poliovirus

Abortive poliomyelitis

48

Causes herpangina, hand foot and mouth dse. Hemorrhagic conjunctivitis

Coxsackie A

49

MCC of viral myocarditis

Coxsackie B

50

MCC of aseptic meningitis

Enteroviruses -Coxsackie

51

Most important test for Hepa A

Anti HAV IgM

52

Also known as enterovirus 72

Hepa A virus

53

Hepa virus high mortality in pregnant

Hepa E (caliciviridae)

54

MCC of nonbacterial GE in adults

Norwalk virus (norovirus)

55

MCC of childhood diarrhea

Rotavirus

56

Naked RNA
CPR

Picorna
Calici
Reo

57

Major antigens of influenza

Hemagglutinin
Neuroaminidase

58

MCC of RT infections

Influenza

59

Degrades protective layer of mucus in RT found in influenza
Cleaves sialic acid to release virus progeny

Neuraminidase

60

Initiates infection of cell by influenza
Neutralized by antibody

Hemagglutinin

61

Antigenic shifts causing pandemics

Influenza A

62

Epidemics due to antigenic drifts

Influenza B

63

DOC for influenza

Oseltamivir
Zanamivir

64

DOC for influenza A

Amantadine
Rimantidine

65

Paramyxoviruses
Envelope spikes

Parainfluenza
RSV
Measles
Mumps

66

Warthin finkleday bodies

Rubeola

67

SOD of mumps

Parotitis
Orchitis
Meningitis

68

Most Impt cause of pneumonia and bronchiolitus in infants

RSV

69

Ttt for RSV

Ribavirin

70

Causes croup with steeple sign
Inspiratory stridor

Parainfluenza 1 and 2

71

Ttt for croup

Racemic epinephrine

72

Bullet shaped enveloped virus

Rabies virus

73

Cause of early death in rabies

Early brainstem encephalitis

74

Virus with club shaped spikes

Coronavirus

75

Reservoir horseshoe bat
Intermediate host civet cat

Corona virus

76

Atypical pneumonia progressing to ARDS

SARS

77

In SARS, coronavirus attaches to what receptor

Ace 2 receptor

78

Non cavitary ground glass infiltrates

Sars

79

Breakbone fever

Dengue virus (flaviviridae)

80

Most prevalent blood borne antigen

Hepatitis C (flavivirus)

81

Dx test for hepa C

Anti HVC
HVC Rna

82

With liver specific microRNA

Hepatitis C

83

Hepatitis with highest chronic carrier rate

Hepatitis C

84

Main cause of essential mixed cryoglobulinemia

Hepatitis C

85

MC indication for liver transplantation

Hepatitis C

86

3 day rash with post LAD

Rubella (togaviridae)

87

Immune complex polyarthritis in adults

Rubella (togaviridae)

88

Congenital rubella syndrome assoc abnormalities

PDA
Blueberry muffin rash
Sensorineural hearing loss
Cataracts
MR

89

Converts single strand RNA to double strand dna

Reverse transcriptase

90

Major capsid protein in HIV
Serologic marker
Located in core

P24

91

HIV fusion protein with host cell

Gp41

92

HIV attachment protein interacts with CD4
Rapid change in antigenicity

Gp120

93

Directs entry of DNA provirus to nucleus
Essential for viral assembly

P17

94

Structural HIV genes

Gag
Pol
Env

95

Regulatory gene in HIV
Activation of transcription of viral genes

Tat

96

Regulatory gene in HIV that decreases CD4 and class 1 MHC proteins

Nef

97

Phase of seroconversion in HIV

Phase 2

98

Cause of chronic diarrhea in aids

C. Parvum

99

Aids illnesses CD4

CMV retinitis
M. Avium pulmo dse
Histoplasmosis

100

Aids illnesses CD4

Disseminated Tb
HSV esophagitis
Esophageal candidiasis
Kaposi's sarcoma

101

Aids illnesses CD4

PCP pneumonia
Cerebral toxoplasmosis
Cryptococcus meningoenceph
Coccidiomycoses - c. Immitis
Chronic diarhhea - c. Parvum

102

For HIV prognostication

PCR

103

HAART

Two nucleoside inhibitors
Zidovudine lamivudine

Protease inhibitor
Indinavir

104

Retrovirus causing adult t cell leukemia and myelopathy

HTLV

105

Malignant t cells with flower shaped nucleus

HTLV

106

Thread like viruses
Longest viruses

Ebola

107

Flavivirus
Bird mosquito man cycle
Neuroinvasive dse

West nile virus

108

MCC of epidemic encephalitis

Japanese B encephalitis

109

Jap B virus transmitted by

Culex spp

110

Jap B enceph on CT scan

Thalamuc infarcts

111

Only live vaccine given to AIDS

MMR