Virology > Virus Pathogenesis > Flashcards

Virus Pathogenesis Flashcards

(84 cards)

Study These Flashcards
1
Q

virulence

A

measure of the degree of pathogenicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T/F the higher the ID50 and LD50, the more virulent the organism.

A

F: less virulent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

possible outcomes of virus-host interactions

A
  • exposure without infection
  • subclinical infection
  • mild disease
  • moderate disease
  • severe disease
  • death!!!!
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

pathogenesis of viral infection

A
  • entry of viruses and primary replication
  • spread, tropism, infection of target organs
  • virus-cell interactions, secondary replication
  • tissue and organ injury
  • shedding
  • death
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

skin defenses

A
  • dense outer layer of keratin
  • low pH
  • presence of fatty acids
  • bacterial flora
  • dryness
  • innate and adaptive immunity (migratory DC = Langerhans cells)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What route does blue tongue virus use to enter a host?

A

bite of arthropods (culicoides)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

3 mucous membranes that can serve as routes of entry?

A
  1. conjunctiva
  2. oropharynx
  3. genitourinary tract
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

mucous membrane defenses

A

IgA

virucidal proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

GI tract defenses

A
  • mucous membrane of oral cavity and esophagus
  • acidity of stomach
  • alkalinity of intestine
  • layer of mucus covering gut
  • lipolytic activity of bile
  • proteolytic activity of pancreatic enzymes
  • defensins
  • IgA
  • scavenging macrophages
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Respiratory defenses

A
  • mucociliary blanket (moves stuff along)
  • alveolar macrophages
  • NALT
  • BALT
  • temp gradient
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What facilitates viruses reaching the subepithelial layers?

A
  1. inflammatory response to virus and/or destruction of epithelium
  2. transport pathways like transcytosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

disseminated infection

A

infection spreads beyond the primary site of infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

systemic infection

A

if a number of organs or tissues are infected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What kind of release facilitates virus dispersal?

A

apical release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What kind of release facilitates systemic spread?

A

basolateral release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

lymphatic spread

A

targeted migration and replication of virus within phagocytic leukocytes, specifically DC and macrophages, lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

viremia

A

presence of virus in the blood; may be free in blood or in a cell (lymphocyte)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

primary viremia

A

initial entry of virus into blood after infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

secondary viremia

A

virus has replicated in major organs and once more entered circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

passive viremia

A

direct inoculation of virus in blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Examples of passive viremia?

A

bite of arthropods or contaminated syringe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

active viremia

A

viremia following initial virus replication in host; release of virions from initial site of replication, such as lymphatics or epithelium of intestine to bloodstream

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

When would passive viremia occur?

A

day 0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

When would primary viremia occur?

A

day 1-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
When would secondary viremia occur?
day 3-14
26
Do macrophages always kill viruses?
NO; virions may be phagocytosed and may replicate in macs and came emigrate through walls of small blood vessels as trojan horse
27
Trojan horse
viruses enter monocyte in lumen of blood vessel and cross blood tissue barrier then leave monocyte in the tissue
28
3 ways to clear virus from bloodstream
1. mononuclear phagocytes in spleen, liver, bone marrow 2. antibody clearance 3. complement-mediated clearance
29
neurotropic virus
viruses that infect neural cells by neural or hematogenous spread
30
neuroinvasive virus
viruses that enter CNS after infection of a peripheral site
31
neurovirulent virus
viruses that cause disease of nervous tissue, manifested by neuro symptoms and often death
32
Is neuroinvasiveness and neurovirulence high or low for herpes simplex virus?
neuroinvasiveness: low neurovirulence: high
33
Is neuroinvasiveness and neurovirulence high or low for Mumps virus?
neuroinvasiveness: high? neurovirulence: low
34
Is neuroinvasiveness and neurovirulence high or low for rabies virus?
high for both! | 100% lethality unless antiviral therapy administered shortly after infection
35
neural spread of viruses
- within axons - in perineural lymphatics - in endoneural space - via infected Schwann cells
36
retrograde spread
travel opposite direction of nerve impulse flow; invades axon terminals then spreads to dendrite or cell body, then crosses synapse to reach next axon terminal
37
anterograde spread
travel in direction of nerve impulse flow; virus invades dendrites or cell bodies and spreads to axon terminals, then crosses synaptic contacts to invade next dendrite
38
centripetal movement
towards CNS
39
centrifugal movement
from CNS within peripheral nerves to other locations in the body
40
T/F neural spread of viruses can occur through olfactory routes
T: anterograde up olfactory nerve to CNS (olfactory bulb)
41
methods to spread viruses through BBB
1. increasing permeability of endothelial cells through secretion of TNF 2. breakdown of endothelial cell junctions through MMP 3. trojan horse (trafficked by monocytes)
42
Is the incubation period long or short for systemic acute infections ?
long
43
What is the duration of immunity for localized acute infections?
variable, may be short | lifelong for systemic
44
T/F secretory IgA is important for localized acute infections?
T : veryyyy
45
T/F the shedding of infectious virions is crucial to the maintenance of infection in populations
T
46
How are acute infections shed?
intensive shedding over a short time period
47
How are persistent infections shed?
shed at lower titers for months to years
48
tropism
specificity/affinity of a virus for a particular host tissue
49
pantropic viruses
can replicate in more than one host organ/tissue
50
rash
general term applied to any temporary eruption on the skin
51
What disease causes a bulls eye rash?
Lyme disease
52
vesicle on skin
small distinct elevation with fluid localized = papilloma disseminated = lumpy skin disease
53
ulcer
opening in skin caused by sloughing of necrotic tissue, extending past epidermis
54
nodule
palpable, solid, elevated mass with distinct borders | *extends deep into dermis = tumor
55
warts
benign skin growths that appear when a virus infects the top layer of skin
56
papule
solid elevations without fluid with sharp borders
57
erythema
reddening of skin, consequence of systemic viral infections (endothelial injury in blood vessels throughout body, including those of subcutaneous tissues)
58
GI tissue injury
destruction of enterocytes -> malabsorption, diarrhea, dehydration, acidosis, hemoconcentration
59
viral-bacterial synergism
when the respiratory tract is infected with both virus and bacteria the % mortality is greater than each alone combined
60
Which virus causes progressive demyelination?
canine distemper
61
What disease can cause neuronal vacuolation?
Prion disease
62
Petechiae hemorrhage
pin point /small spots
63
ecchymoses hemorrhage
larger areas of hemorrhage, ill defined margins
64
disseminated intravascular coagulation (DIC)
complication arising from viral infections of blood vessels; widespread activation of clotting cascade -> blood clots in small blood vessels throughout body
65
What happens when clotting proteins in blood are used up in DIC?
severe bleeding can occur from various sites
66
teratogenesis
abnormal development or arrests in development of embryo or fetus -> death or malformations during antenatal period
67
What can cause congenital hydraencephaly in calves and how does it present?
BVDV -> recumbence, depression, dome shaped skull
68
What happens to a non-pregnant animal with BVDV?
usually mild infection, scours, milk drop, reduced WBCs
69
What happens when a pregnant cow has a transient infection of BVDV?
naturally immune
70
What occurs when a cow with a 1 month pregnancy has BVDV?
embryo death
71
What occurs when a cow with 2-4 month pregnancy has BVDV?
persistent infection (PI calves) -> immunotolerant
72
What occurs when a cow with 5-9 month pregnancy has BVDV?
middle: abortion, deformities late: normal calves
73
What is the danger of an immunotolerant calf?
the virus can mutate to become cytopathic and cause a superinfection -> can infect other viremic animals and lead to fatal mucosal disease
74
virus induced immunopathology
tissue injury mediated by host immune response to virus infection; cause of damage with viruses that are persistent -> chronic immune response
75
What happens when NO and superoxide are produced in abundance?
cell damage! normally inhibit viral replication
76
When do antibody mediated inflammatory reactions involve toxicity?
- engagement of IgG with Fc receptors on inflammatory cells which causes inflammatory release - following deposition of viral antigen-antibody complexes in capillary beds, leading to activation of complement cascade
77
What causes immune complex-mediated vasculitis and what is a common sign?
feline infectious peritonitis; distended abdomen
78
What can happen when macrophages release IL10?
skew immune response from TH1 to TH2 -> diminishes cell-mediated immunity
79
infectious bursal disease
virus replication causes atrophy of bursa and deficiency of B lymphocytes resulting in immunosuppression
80
inapparent infections
clinical signs and symptoms are not evident; too few cells may be infected
81
persistent infection
pathogen not cleared efficiently by adaptive immune response -> infectious virus demonstrable continuously whether or not there is ongoing disease
82
latent infection
infectious virus not demonstrable except when reactivation occurs -> often stimulated by immunosuppression and/or action of cytokine or hormone (ex. cold sores)
83
chronic infection
virus continuously shed from or is present in infected tissue; sometimes starts as acute infection (ex. foot and mouth disease in cattle)
84
slow infection
prolonged incubation period, lasting months or years; quantities of infectious virus gradually increase during a very long preclinical phase; slow lethal progressive disease (ex. prions)
Virology
flashcards
Decks in class (16)
# Cards
Brainscape helps you reach your goals faster, through stronger study habits.
© 2026 Bold Learning Solutions. Terms and Conditions