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PBD FINAL > Viruses I > Flashcards

Viruses I Flashcards

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1
Q

RNA dependent RNA polymerase

A

negative strand RNA

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2
Q

reoviridae

A

double strand RNA

-rotavirus

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3
Q

rotavirus

A

has double strand RNA

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4
Q

smallest free living organism

A

mycoplasm

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5
Q

DNA viruses

A 
HHAPPPy
herpes
hepadena
adeno
papova
parvo
pox
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6
Q

parvo

A

single strand DNA

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7
Q

pox

A

dsDNA

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8
Q

orthmyxoviridae

A

RNA virus

-epidemic influenzas

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9
Q

fever, chills, HA, aches, dry cough, sore throat, rhinorrhea

A

influenza

-orthmyxoviridae

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10
Q

structure of orthmyxoviridae

A

spherical - RNA in 8 segments
HA and NA glycoproteins

HA - agglutination of RBCs
NA - cleaves mucin

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11
Q

orthmyxoviridae that invades humans

A

type A

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12
Q

antigenic drift

A

epidemics

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13
Q

antigenic shift

A

pandemics

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14
Q

reyes syndrome

A

children with influenza who take aspirin

-brain and liver problems

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15
Q

bird flu in 1997

A

1997

had diffuse patchy infiltrates with consolidation on chest Xray

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16
Q

new threat for pandemic flu

A

H7N9

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17
Q

spanish flu in 1918

A

H1N1

and 2009

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18
Q

negative single strand RNA
F protein
HA and NA on same spike

A

paramyxoviridae

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19
Q

flu like symptoms with cold and croup, stridor

A

parainfluenza virus

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20
Q

number 1 cause of pneumonia in infants less than 6 months

A

respiratory syncytial virus
RSV

-get giant cells - due to F protein

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21
Q

number 2 cause of lower respiratory illness in children around 1 year old

A

metapneumovirus

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22
Q

parainfluenza virus

A

flu like with cold symptoms and stridor

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23
Q

RSV

A

pneumonia in infants less than 6 month with giant cellsRSV

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24
Q

metapneumovirus

A

lower respiratory illness in children around 1 year old

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25
parotid gland swelling and orchitis
mumps
26
conjunctivitis, photophobia, fever, cough, rhinitis, malaise, followed by spots in mouth and head to toe rash
measles
27
kopliks spots
in measles | -red and bluein mouth
28
complications of measles
subacute sclerosing panencephalitis - measles in adolescents - slow CNS deterioration
29
measles in adolescents who has slow CNS deterioration
subacute sclerosing panencephalitis
30
RNA hepatitis
A, C, D, E, G
31
DNA hepatitis
B
32
fever, aches, jaundice, elevated liver enzymes
acute viral hepatitis
33
enlarged tender liver, mild liver enzyme elevation
chronic viral hepatitis with hep B, C, D
34
liver enzymes
AST, ALT - hepatocytes | alkaline P, GGT - bile canaliculi
35
acute viral hepatitis in young children
hepatitis A | + RNA icosahedral
36
active hepatitis A infection
IgM HAV
37
old hepatitis A infection
IgG HAV
38
dane particle
hepatitis B | -DNA, icosahedral
39
hepatitis B
hospital workers at risk
40
anti HBsAg
immunity to hep B
41
HBcAg IgM
new hep b infection
42
HBcAg IgG
old hep b infection
43
HBeAg
high hep b infectivitiy
44
anti-HbeAg
low hep b infectivitiy
45
path of hep B
acute hepatitis fulminant hepatitis - liver destruction chronic hepatitis -co-infection with hepatitis D
46
hepatitis D
co-infection with B - superinfection - fulminant, chronic, cirrhosis, increased mortality
47
complications of hep B
primary hepatocellular carcinoma
48
primary hepatocellular carcinoma
with hep B infection increased risk 200x
49
number 1 cause of chronic hepatitis
hepatitis C -RNA icosahedral IV drug use
50
IV drug use
hepatitis C
51
hepatitis in asia, india, africa
hepatitis E
52
watery diarrhea, RLQ pain, rose spots, fever
salmonella typhi
53
watery diarrhea, RLQ pain, pseudoappendicitis
y. enterocolytica
54
localized urethritis with serous mucus discharge
ureaplasma urealytica -normal flora in women mycoplasm - no cell wall urea splitter
55
pyelonephritis, urethritis, cystitis, in immunocompromised
proteus mirabilis urea splitter
56
inclusion bodies
cytomegalovirus
57
bone marrow vs. AIDS - CMV infection
AIDS - eye symptoms | bone marrow - pulmonary symptoms
58
tropics paralytic disease
HTLV-1
59
HIV-1
US
60
HIV-2
west africa
61
p24
capsid of HIV | -used for diagnosis
62
gp160
HIV - binds CD4 - consists of gp120 and gp41
63
env gene
in HIV | -gp120 hypervariable region
64
decreased CCR5
resistant to HIV
65
stages of HIV infection
1 - acute viral illness 2 - clinical latency 3 - AIDS
66
acute viral illness with HIV
viremia, fever, malaise, lymphadenopathy, pharyngitis
67
clinical latency with HIV
gradual CD4 T cell destruction | -no symptoms
68
AIDS
``` T cell < 200 -or opportunistic infections: candida albicans pneumocystic cartnii kaposi sarcoma ```
69
HIV count measures
speed of infection
70
CD4 count measures
progression of infection
71
multinucleated giant cells
in HIV - transmission of HIV with T cell fusion
72
hypergammaglobulinema
can be seen in AIDS
73
constitutional illness
AIDS | -sweats, fever, lymph node swelling, weight loss, wasting
74
malignancies with AIDS
B cell lymphoma - brain mass kaposi sarcoma - HHV-8 co-factor - red purple nodules on skin all over body invasive cervical squamous cell carcinoma
75
B cell lymphoma
AIDS patients | -mass in brain
76
kaposi sarcoma
red purple nodules on skin all over body - AIDS patients - associated with HHV-8 cofactor

PBD FINAL (10 decks)

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