W8 Lec [Sub] - Plasma Complement Regulators

Question 1

C1 inhibitor (C1INH): molecular weight (KD)?

Answer 1

105

Question 2

C1 inhibitor (C1INH): concentration (mg/mL)?

Answer 2

240

Question 3

C1 inhibitor (C1INH): function?

Answer 3

Dissociates C1r and C1s from C1q

Question 4

Factor I: molecular weight (KD)?

Answer 4

88

Question 5

Factor I: concentration (mg/mL)?

Answer 5

35

Question 6

Factor I: function?

Answer 6

Cleaves C3b and C4b

Question 7

Factor H: molecular weight (KD)?

Answer 7

150

Question 8

Factor H: concentration (mg/mL)?

Answer 8

300-450

Question 9

Factor H: function?

Answer 9

Cofactor with I to inactivate C3b; prevents binding of B to C3b

Question 10

C-4 binding protein: molecular weight (KD)?

Answer 10

520

Question 11

C-4 binding protein: concentration (mg/mL)?

Answer 11

250

Question 12

C-4 binding protein: function?

Answer 12

Acts as a cofactor with I to inactivate C4b (C4bp)

Question 13

S protein is also called?

Answer 13

vitronectin

Question 14

S protein: molecular weight (KD)?

Answer 14

84

Question 15

S protein: concentration (mg/mL)?

Answer 15

500

Question 16

S protein: function?

Answer 16

Prevents attachment of the C5b67 complex to cell membranes