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HEME/LYMPH > WBC Disorders V > Flashcards

WBC Disorders V Flashcards

(52 cards)

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1
Q

BCL6 dysregulation

A

diffuse large B cell lymphoma

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2
Q

most common form of NHL in US

A

DLBCL

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3
Q

t(14;18)

A

DLBCL

same as follicular

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4
Q

EBV and KSHV/HHV-8

A

associated with DLBCL

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5
Q

EBV and DLBCL

A

severe T cell deficiency

with DLBCL

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6
Q

KSHV/HHV8

A

primary effusion in malignant pleural effusion

with DLBCL

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7
Q

DLBCL demo

A

adults 60yo

also children and young adults

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8
Q

DLBCL prognosis

A

aggressive
-rapidly fatal without tx

chemo - good prognosis

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9
Q

rapidly growing mass at waldeyers ring

A

DLBCL

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10
Q

two classes of DLBCL

A

BCL6 and BCL2 rearrangement

BCL2 - though to be morph of follicular lymphoma

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11
Q

starry sky pattern

A

burkitt lymphoma

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12
Q

categories of burkitt lymphoma

A

african endemic
sporadic non-endemic
HIV

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13
Q

C-myc oncogenes

A

burkitt lymphoma

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14
Q

translocation of C-myc on chromosome 8

A

ALL burkitt lymphomas

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15
Q

mandibular burkitt

A

african - endemic

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16
Q

GI burkitt

A

sporadic - non-endemic

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17
Q

aggressive burkitt

A

HIV

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18
Q

fastest growing human tumor

A

burkitt

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19
Q

EBV and burkitt

A

all endemic
25% HIV
15-20% sporadic

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20
Q

warburg effect

A

in burkitt

MYC oncogene

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21
Q

NO BCL2

22
Q

burkitt demo

Study These Flashcards
A

adolescents or young adults with extranodal masses

23
Q

most common and deadly plasma cell dyscrasia

Study These Flashcards
A

multiple myeloma

24
Q

t(8;14)

Study These Flashcards
A

translocation involving MYC gene - burkitt lymphoma

25
rouleaux formation
multiple myeloma due to high M proteins
26
path fractures, hypercalcemia, renal failure, immune abnormalities
multiple myeloma
27
flame cells, mott cells, russel bodies (cyto inclusion), and dutcher bodies (nuclear inclusions)
multiple myeloma
28
bence joines proteins
light chains in urine toxic to renal tubular cells can lead to myeloma kidney
29
most common multiple myeloma
monoclonal IgG-kappa
30
CD138, syndecan 1, CD56
multiple myeloma
31
definitive diagnosis of multiple myeloma
bone marrow examination
32
most common plasma cell dyscrasia
MGUS
33
dx of MM
>3g/dL of monoclonal Igs in serum
34
single mass in bone or soft tissue
solitary myeloma (plasmacytoma) uncommon
35
lack of sx and high plasma M component
smoldering myeloma
36
multiple myeloma demo
men, african, 65-70yo
37
most myelomas
>3g serum Ig | and/or >6g bence jones proteinuria
38
solitary plasmacytoma
solitary lesion progress to MM 10-20 yrs extraosseous - cure if resection -often upper respiratory
39
smoldering myeloma
asymptomatic with M protein >3g serum prgress to MM 15 yrs middle ground of MM and MGUS
40
multiple myeloma prognosis
survival 4-7 yrs untreated 6-12 months cyclin D1 - good prognosis deletion 13, 17, t(4;14) - bad prognosis
41
confusion, lethargy, constipation, renal dysfunction, bacterial infections
multiple myeloma CNS - from hypercalcemia
42
monoclonal gammopathy of uncertain significance
asymptomatic and serum Ig < 3g/dL early stage of multiple myeloma development **should periodically assess patient for serum M component and bence-jones proteins in urine
43
lymphoplasmacytic lymphoma
B cell neoplasm 60-70yo fraction to plasma cells secretes IgM - high levels -lead to hyperviscosity - waldenstrom
44
waldenstrom macroglobulinemia
hyperviscosity due to large IgM release with lymphoplasmacytic lymphoma
45
hyperviscosity leads to
visual impairment - venous congestion neuro problems - HA, dizzy, deaf - sluggish blood flow bleeding cryoglobulinemia - precipitate at low T - raynauds, urticaria
46
lymphoplasmacytic lymphoma prognosis
incurable - IgM alleviated with plasmapharesis - also temp tx is anti-CD20 Ab survival 4 years
47
overexpression of cyclin D1
mantle cell lymphoma
48
t(11;14)
mantle cell lymphoma -IgH on 14 and cyclin D on 11 overexpression of cyclin D1 -more G1 to S transition fluorescence in situ hybridization
49
painless lymphadenopathy, spleen and gut sx
mantle cell lymphoma
50
mantle cell lymphoma prognosis
incurable - survival 3-4 yrs organ dysfunction caused by tumor infiltration HSC transplant - some promise
51
lymphomatoid polyposis
mantle cell lymphoma
52
cyclin D1, CD19, CD20, CD5, no CD23
mantle cell lymphoma

HEME/LYMPH (11 decks)

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