WBC Disorders VI

Question 1

maltomas

Answer 1

marginal zone lymphoma

Question 2

extranodal marginal zone lymphomas

Answer 2

continuum between reactive hyperplasia and lymphoma

begin as polyclonal

Question 3

sjogren

Answer 3

salivary - may lead to marginal zone lymphoma

Question 4

hashimotos

Answer 4

thyroiditis - may lead to marginal one lymphoma

Question 5

helicobacter

Answer 5

h. pyloric - chronic gastritis - may lead to marginal zone lymphoma

Question 6

BRAF mutation

Answer 6

hairy cell mutation

Question 7

prognosis of hairy cell

Answer 7

excellent

-gentle chemo - remission

Question 8

atypical mycobacterial infections

Answer 8

hairy cell leukemia

Question 9

hairy cell leukemia demo

Answer 9

middle age white male

55yo

Question 10

dry tap

Answer 10

hairy cell leukemia

fibrosis of marrow

Question 11

massive splenomegaly

Answer 11

hairy cell leukemia

Question 12

massive splenomegaly, atypical mycobacterial infection, pancytopenia

Answer 12

hairy cell leukemia

Question 13

far east

Answer 13

more common to have T cell/NK cell neoplasms

Question 14

gene rearrangement in ALK on chromosome 2p23

Answer 14

anaplastic large cell lymphoma

also CD30

Question 15

hallmark cells

Answer 15

anaplastic large cell lymphoma

large anaplastic cells with horseshoe nuclei and voluminous cytoplasm

Question 16

cluster around venules and infiltrate lymphoid sinuses

Answer 16

anaplastic large cell lymphoma

Question 17

peripheral T cell lymphoma, unspecified

Answer 17

lymphadenopathy, eosinophilia, pruritis, weight loss

not good prognosis

Question 18

anaplastic large cell lymphoma prognosis

Answer 18

children with ALK - good

adults no ALK - bad

Question 19

CD30+

Answer 19

anaplastic large cell lymphoma

and hodgkins

Question 20

HTLV-1 infection

Answer 20

adult T cell leukemia/lymphoma

japan, w. africa, caribbean

Question 21

adult T cell leukemia/lymphoma

Answer 21

demyelinating disease of CNS and spinal cord

Question 22

clover leaf, flower cells

Answer 22

adult T cell leukemia/lymphoma

Question 23

adult T cell leukemia/lymphoma prognosis

Answer 23

rapidly progressive
-fatal

only skin - more indolent course

Question 24

tumor of CD4 helper T cells that homes to skin

Answer 24

mycosis fungoides

Question 25

3 stages of mycosis fungoides

Answer 25

pre-mycotic - inflammation plaque tumor

Question 26

cerebriform tumor cells

Answer 26

mycosis fungoides sezary cells

Question 27

exfoliative erythroderma

Answer 27

sezary syndrome mycosis fungoides

Question 28

sezary syndrome

Answer 28

skin involvment of mycosis fungoides with exfoliative erythroderma sezary cells - cerebriform nuclei

Question 29

STAT3 mutation

Answer 29

large granular lymphocytic leukemia

Question 30

large granular lymphocytic leukemia

Answer 30

NK/T cell large lymphocytes - blue cytoplasm and azurophilic granules neutropenia/anemia**

Question 31

felty syndrome

Answer 31

rheumatoid arthritis splenomegaly neutropenia with large granular lymphocytic leukemia

Question 32

T cell LGLL

Answer 32

indolent

Question 33

NK cell LGLL

Answer 33

aggressive

Question 34

nasopharyngeal mass

Answer 34

extranodal NK/T cell lymphoma large azurophilic granules

Question 35

extranodal NK/T cell lymphoma

Answer 35

EBV association aggressive prognosis

Question 36

extranodal NK/ T cell lymphoma prognosis

Answer 36

no chem response responds to radiation**

Question 37

hodgkins demo

Answer 37

32yo average age - young adults/adolescents - also older adults curable - most cases

Question 38

reed sternberg cells

Answer 38

giant B cell - in hodgkins lymphoma release cytokines, chemokines and other factors that induce accumulation of reactive lymphocytes, macros, and granulocytes aneuploid

Question 39

hodgkins lymphoma

Answer 39

single node then spread in contiguous fashion | -can be staged

Question 40

epigenetic changes

Answer 40

reed sternberg cells in hodgkins

Question 41

owl eye nuclei

Answer 41

reed sternberg cells

Question 42

variants of RS cells

Answer 42

mononuclear lacunar - folded nucleus, multilobated lymphohistiocytic - polyploid nuclei

Question 43

types of hodgkins

Answer 43

``` 1 nodular sclerosis 2 mixed cellularity 3 lymphocyte rich 4 lymphocyte depletion 5 lymphocyte predominance ``` first 4 - CD15, CD3 5 - CD20 1, 5 - no EBV

Question 44

nodular sclerosis

Answer 44

type 1 hodgkins - good prognosis - CD15, CD30 - no EBV - lower cervical, supraclavicular nodes

Question 45

mixed cellularity

Answer 45

type 2 hodgkins - EBV associated - CD15, CD30 - males, night sweats, weight loss - good prognosis

Question 46

lymphocyte-rich

Answer 46

type 3 hodgkins - EBV associated - CD15, C30 - excellent prognosis

Question 47

lymphocyte depletion

Answer 47

type 4 hodgkins - EBV associated - CD15, CD30 - elderly, HIV, non-industrialized - worse prognosis than first 3

Question 48

lymphocyte predominance

Answer 48

type 5 hodgkins - no EBV association - CD20/BCL6 - lymphohistiocytic cells - popcorn cells may transform to DLBCL

Question 49

first 4 hodgkins types

Answer 49

classic**

Question 50

hodgkin vs. NHL

Answer 50

hodgkin - single group of nodes - orderly spread - extranodal presentation - rare - no waldeyer or mesenteric node involvement

Question 51

helminths

Answer 51

Th2

Question 52

intracellular pathogen

Answer 52

Th1

Question 53

extracellular pathogen/fungi

Answer 53

Th17