WBC Disorders VII

Question 1

3 categories of myeloid neoplasia

Answer 1

1 - acute myeloid leukemia
2 - myelodysplastic syndrome
3 - myeloproliferative disorder

Question 2

accumulation of immature myeloid forms in bone marrow supress normal hematopoiesis

Answer 2

AML

Question 3

Dx of AML

Answer 3

20% blasts in bone marrow

Question 4

ineffective hematopoiesis leads to cytopenia

Answer 4

myelodysplastic syndromes

Question 5

increased production of one or more types of committed mature white,red cells of myeloid series

Answer 5

myeloproliferative disorders

Question 6

transform to AML

Answer 6

MDS and MPD

Question 7

origin from hematopoietic progenitor cell

Answer 7

myeloid neoplasias

Question 8

CD34

Answer 8

multipotent stem cells

Question 9

CD64

Answer 9

mature myeloid cells

Question 10

CD15

Answer 10

mature myeloid cells

Question 11

AML with prior MDS

Answer 11

poor prognosis

Question 12

therapy related AML

Answer 12

very poor prognosis

Question 13

AML, NOS

Answer 13

M0-7 classes

Question 14

t(8;21) (q22;q22)

Answer 14

favorable prognosis AML

RUNX1/ETO fusion gene

M2

Question 15

inv(16) (p13;q22)

Answer 15

favorable prognosis AML

CBFB/MKH11 fusion gene

M4eo

Question 16

t(15;17) (q22;11-12)

Answer 16

intermediate prognosis AML

RARA/PML fusion gene

M3

Question 17

t(11q23;v)

Answer 17

poor prognosis AML

MLL fusion gene

M4/M5

Question 18

myeloperoxidase

Answer 18

identify myeloblast

Question 19

nonspecific

Answer 19

identify monoblasts

Question 20

auer rods

Answer 20

identify myeloid lineage

Question 21

myeloperoxidase negative AML

Answer 21

M0 - minimally differentiated

Question 22

myeloperoxidase positive AML

Answer 22

M1 - AML without maturation

Question 23

non-specific esterase positive AML

Answer 23

M5 - AML with monocytic maturation

Question 24

AML path

Answer 24

disruption of gene encoding transcription factors for normal myeloid differentiation

epigenome effects

Question 25

t(15;17)

Answer 25

acute promyelocytic leukemia M3

Question 26

acute myeloid leukemia without maturation

Answer 26

M1 subtype -flow cytometry + for CD34, CD33, CD15 (subset) - for CD64 myeloid cells showing limited maturation

Question 27

acute promyelocytic leukemia

Answer 27

M3 t(15;17) show auer rods

Question 28

acute myeloid leukemia with monocytic differentiation

Answer 28

M5b subtype

Question 29

severe bleeding from gums

Answer 29

AML -acute myeloid leukemia fatigue, fever, infection, bleeding

Question 30

clinical for AML

Answer 30

fatigue - anemia infection - neutropenia bleeding - thrombocytopenia

Question 31

granulocytic sarcoma

Answer 31

localized primary tumor mass with AML

Question 32

leukemia cutis

Answer 32

monocytic feature monocytic differentiation - often with skin infiltration

Question 33

antibodies against GpIIb/IIIa or vWF

Answer 33

AML with megakaryocytic maturation M7

Question 34

AML with erythroid maturation

Answer 34

M6

Question 35

AML with myelomonocytic maturation

Answer 35

M4 AMML monocytic and myelocytic differentiation MPO positive NSE positive

Question 36

M0

Answer 36

AML minimally differentiated MPO negative

Question 37

acute promyelocytic leukemia

Answer 37

M3 - high incidence of DIC - t(15;17) association

Question 38

t-MDS

Answer 38

secondary myelodysplasia syndrome to genotoxic drug or radiation therapy worse prognosis and worse cytopenia

Question 39

mutation at TP53

Answer 39

LOF mutation in myelodysplasia syndrome

Question 40

clinical for myelodysplasia

Answer 40

70yo progress to AML 10-40%

Question 41

pseudo-peiger-huet cells

Answer 41

neutrophils with only two nuclear lobes in myelodysplasia

Question 42

megakaryocytes with multiple nuclei

Answer 42

in myelodysplasia

Question 43

ringed sideroblasts

Answer 43

erythroid progenitors with iron laden mitochondria seen as blue perinuclear granules in myelodysplasia

Question 44

discovered on accident on blood screen

Answer 44

often with myelodysplasia

Question 45

MDS prognosis

Answer 45

survival 9-29 months

Question 46

constitutively activated tyrosine kinases

Answer 46

myeloproliferative disorders