WBC Function

Question 1

Neutrophil function

Answer 1

Majority of peripheral WBCs
Phagocytosis
Destruction of microorganisms
Contain pyrogen

Question 2

Eosinophil function

Answer 2

Allgery
Parasitic infection
Inflammation (asthma)
Phagocytosis

Question 3

Basophil function

Answer 3

Inflammation
Hypersensitivity
Anaphylaxis - IgE receptors, Degranulation, Vasoactive, bronchoconstrictive, chemotatic
Tissue Basophil = mast cell

Question 4

T cells

Answer 4

Precursors migrate to Thymus and matures here
Helper, suppressor, cytotoxic - different T cell forms
60-80% of peripheral blood lymphs
Markers: Tdt, CD4, CD8
NK cells can kill foreign antigens without antibodies

Question 5

B cells

Answer 5

Bone marrow
Antibody production
Markers: Surface Ig, CD34, CD19

Question 6

Monocyte

Answer 6

Phagocytosis
Inhibit bacterial growth
Removes old cells
Antigen processing - involved with innate and adaptive
Scavenger
Primarily a tissue cell

Question 7

Answer 7

Hypersegmented Neutrophils
5-6 lobes
Response to infection

Question 8

Answer 8

Hypsegmented Neutrophils
Normal function
Two lobes connected with thin filament

Question 9

Answer 9

Dohle Bodies
Aggregates of Endoplasmic Reticulum
Toxic change

Question 10

Answer 10

Toxic Granulation
Associated with infection
Granules stain with dark-blue/black

Question 11

Answer 11

Vacuoles
Associated with infection, artefact, fat, end stage of microogranism digestion

Question 12

Answer 12

Auer Rods
Fused Lysosomes

Question 13

Answer 13

Smudge/Basket Cells
Broken cells
Use Albumin to coat WBC to perform differential
May be artefact
>10/100 WBC

Question 14

Answer 14

Russell Bodies - Plasma cells
Immunoglobulin
Mott Cell - lots of vacuoles inside
Flame Cell - Associated with IgA

Question 15

Answer 15

Barr Bodies - no note for differential
“Drumsticks” appearance
Females most notably

Question 16

Answer 16

Blue-green Crystals
Necrotic hepatocytes in setting of acute liver failure