Wednesday - Adrenal/Pancreas histo - Awe Bee Flashcards Preview

Josh Endo week 1 > Wednesday - Adrenal/Pancreas histo - Awe Bee > Flashcards

Flashcards in Wednesday - Adrenal/Pancreas histo - Awe Bee Deck (14):
1

Embryologic origin of 2 parts of the adrenal gland

Cortex: mesoderm
Medulla: neural crest

2

Sympathetic fibers to meduallary chromafin cells are unique in what why?

They are preganglionic.

3

Arterial supply to adrenals:

renal artery has branches
- to cortex
- to medulla
then there are cortical and medullary veins that join to form a collecting vein (suprarenal vein)

4

3 zones of cortex, what they look like and what they produce

zona glomerulosa - outer portion. makes aldosterone and deoxycorticosterone

zona fasiculata - middle portion, cuboidal cells, lipid drops, parallel cords. makes cortisol and hydrocortisone, some androgens

zone reticularis - a little lipid. some light some dark cells. make sex steroids (androgens)

5

What upregulates aldosterone production in the glomerulosa?

Angiotensin
and ACTH, but acth works in all zones to upregulate production

6

What upregulates production of NE and EPI in medulla?

acetylcholine

7

What kind of cells are in the medulla
what shape are they.

Chromaffin cells
they're columnar, non-regenerative

8

What is unique about chromaffin cells? (hint, they're from neural crest)

They're post ganglionic neurons

9

What types of cells are in the pancreatic islets?

alpha - 20%
beta - 70%
delta - 10%
gamma - 1%
epsilon

10

Where are alpha cells located?
what do they make

the periphery of the islets
glucagon

11

Where are beta cells located?
what do they make

center of islet
insulin

12

Where are delta cells located?
what do they make

somewhere in the islet
somatostatin.

13

what do gamma cells make?
what does it do?
what is their other name?

pancreatic polypeptide
- it's similar to somatostatin, stops enzyme secretion of exocrine pancrease
pp cells

14

What type of nerves go to pancreas
what type of blood vessels

sympathetic and parasympathetic

fenestrated capillaries