Flashcards in Wednesday - Adrenal Phys - Trachte Deck (18):
What hormone are needed for cortisol release?
Corticotropin Releasing Hormone (CRH) --> ACTH --> Cortisol (has negative feedback to others)
4 major effects of cortisol:
gluconeogenesis (raise blood glucose levels. lack of cortisol --> hypoglycemia)
CRH is made where?
Gs --> cAMP
CRH leads to synthesis of what?
that is cleaved into what?
Melanocyte Stimulating Hormone
ACTH binds to what receptor?
what type of g protein is it?
Where is it located?
What does ACTH cause in the adrenal cortex
side chain cleavage, turning cholesterol into pregnelolone
Where in the cell are glucocorticoid receptors?
What cells have them?
What do they do?
cytosol, just floatin' around
almost every cell
homodimer --> transcription factor --> regulate immune response and metabolism (6000 genes effected)
Mineralcorticoid receptor is found where?
collecting duct, colon, sweat glands
There is a lot of cortisol and not much aldosterone. How does an aldosterone sensitive tissue have it's response since they have the same affinity
turns the cortisol to cortisone, which has very little affinity for the Mineralcorticoid receptor
Main mineral coorticoid and effects of it
3 Androgens that bind to androgen receptor
How does cortisol get transported
90% bound to to transcortin or albumin
what does cortisol do to bones?
decreases osteoblasts -> osteoperosis
Cushing disease =
Cushing syndrome =
What to you look like?
disease = pituitary adenoma --> ACTH secretion
syndrome = too much cortisol --> decrease ACTH
- buffalo hump
- tine skin
- potbelly and skinny legs
- moon face?
What time are cortisol levels highest?
Primary Addison'e caused by what?
secondary is from what?
immune destruction or congenital --> adrenal insufficiency. decreased cortisol and aldosterone --> increase ACTH
(opposite of cushing's)
symptoms of addison's
hyperpigmentation of skin