Wednesday - Adrenal Phys - Trachte Flashcards Preview

Josh Endo week 1 > Wednesday - Adrenal Phys - Trachte > Flashcards

Flashcards in Wednesday - Adrenal Phys - Trachte Deck (18):
1

What hormone are needed for cortisol release?

Corticotropin Releasing Hormone (CRH) --> ACTH --> Cortisol (has negative feedback to others)

2

4 major effects of cortisol:

immune suppression
gluconeogenesis (raise blood glucose levels. lack of cortisol --> hypoglycemia)
protein catabolism
lipolysis

3

CRH is made where?
acts where?
half life:
receptor type:

Hypothalamus
Anterior pituitary
9 minutes
Gs --> cAMP

4

CRH leads to synthesis of what?
that is cleaved into what?

pro-opiomelanocortin (POMC)

Melanocyte Stimulating Hormone
ACTH
lipotropin

5

ACTH binds to what receptor?
what type of g protein is it?
Where is it located?

melaoncortin
Gs -->cAMP
adrenal cortex

6

What does ACTH cause in the adrenal cortex

side chain cleavage, turning cholesterol into pregnelolone

7

Where in the cell are glucocorticoid receptors?
What cells have them?
What do they do?

cytosol, just floatin' around

almost every cell

homodimer --> transcription factor --> regulate immune response and metabolism (6000 genes effected)

8

Mineralcorticoid receptor is found where?

collecting duct, colon, sweat glands

9

There is a lot of cortisol and not much aldosterone. How does an aldosterone sensitive tissue have it's response since they have the same affinity

turns the cortisol to cortisone, which has very little affinity for the Mineralcorticoid receptor

10

Main mineral coorticoid and effects of it

Aldosterone
water retention

11

3 Androgens that bind to androgen receptor

dehyroepiandrosterone
androstenedione
testosterone

12

How does cortisol get transported

10% free
90% bound to to transcortin or albumin

13

what does cortisol do to bones?

decreases osteoblasts -> osteoperosis

14

Cushing disease =
Cushing syndrome =

What to you look like?

disease = pituitary adenoma --> ACTH secretion
syndrome = too much cortisol --> decrease ACTH

a fool
- buffalo hump
- tine skin
- potbelly and skinny legs
- moon face?

15

What time are cortisol levels highest?

morning

16

Primary Addison'e caused by what?

secondary is from what?

immune destruction or congenital --> adrenal insufficiency. decreased cortisol and aldosterone --> increase ACTH
(opposite of cushing's)

17

symptoms of addison's

Fatigue
anorexia
diarrhea
hyperpigmentation of skin

18

Main glucocorticoid

cortisol