Week 1

Question 1

Describe Haematoepic stem cells

Answer 1

Self renewal (proliferate to form new cells)

Differential (Can change cell type)

Found in bone marrow

Question 2

Haematopoeisos

Answer 2

The process of HSC developing to mature bone cells then released into blood

Question 3

Blasts

Answer 3

Immature blood cells

Question 4

How is Haematopoeisos controlled

Answer 4

HGF - Controls proliferation and differentiation

Question 5

Aplastic anemia

Answer 5

The body stops producing new blood cells

Symptoms: Fatigue, short breath, rashes

Caused by the HSC failure to divide and radiation

Question 6

HSCT stands for

Answer 6

Haematoeiopic stem cell transportation

Question 7

Types of stem cell transplantation

Answer 7

Allogenic - Matched donor

Synegenic - From identical twin

Autolegous - From patient

Question 8

Autologous pros and cons

Answer 8

Low risk of Graft-Versus host disease, Fast IS response, reduced risk of infection

BUT

Risk of reinfusing cancer cells

Question 9

Allogenic pros and cons

Answer 9

GVT can fight cancer, used for genetic disorders

BUT

Inc infection risk and high cost

Question 10

GVHD and how to prevent

Answer 10

Sees donated cells as a threat and attacks

Prevented via - Immuno suppressors

Question 11

Where to get HSCs

Answer 11

Bone marrow, peripheral blood etc

Collected via pelvis

Question 12

Dyes for cell staining

Answer 12

azure - b

easin - y