Week 2

Question 1

What happens to erythrocytes mature to RBC?

Answer 1

Loss of the nucleus, mitochondria and ribosomes (Controls its ability to obtain energy)

Relies on on glycolysis for energy

Question 2

Hypoxia inductible Factor HIF

Answer 2

Causes inc in EPO production allowing increase in RBC production

allows for more 02 to be transported

Question 3

Splenomegolly

Answer 3

Enlarged spleen due to RBC destruction

Question 4

G6P deficiency

Answer 4

Causes decrease in NADPH levels, cells more susceptible to oxidative stress

Symptoms: Jaundice, anaemia

Test: Beutler test (Incubate blood with G6P and NADP… dry and run to produce UV light

Question 5

PK deficiency

Answer 5

Causes a rigid cell shape

Diagnosis:Analyse PK activity / PCR reaction

Treatment: Folate supplements and RBC transfusion

Question 6

IHA

Answer 6

Immune Haemolytic anemias

Question 7

AIHAs

Answer 7

Autoimmune haemolytic anaemias

AB produced against its own RBC

Question 8

Alloimmune haemolytic anaemias

Answer 8

Blood transfusion reactions

RBC from donor reacts

Question 9

Drug induced immune haemolytic anaemias

Answer 9

Drug binds to RBC and acts like a foreign antigen

Triggers AB reaction

Question 10

RBC function

Answer 10

Carries 02 from lungs to tissues
Carries C02 from tissues to lungs

Question 11

BAND3 protein

Answer 11

Acts as an ion channel for CL- and HCO3

Question 12

Glycophorins

Answer 12

Act as transmembrane signal transducers

Question 13

Transferin receptor

Answer 13

Binds transferrin molecules for iron movement

Question 14

Spectrin

Answer 14

6 join to form an actin molecule